TETRAETHYL METHYLENEDIPHOSPHONATE synthesis
- Product Name:TETRAETHYL METHYLENEDIPHOSPHONATE
- CAS Number:1660-94-2
- Molecular formula:C9H22O6P2
- Molecular Weight:288.21
762-04-9
343 suppliers
$10.00/10g
1660-94-2
199 suppliers
$10.00/1g
Yield:1660-94-2 58%
Reaction Conditions:
with sodium in dichloromethane at 0 - 20; for 336 h;Inert atmosphere;
Steps:
Tetraethyl methylenediphophonate 1
The tetraethyl methylenediphosphonate 1 was synthesized by a slightly modified procedure fromliterature1 as follow: A three-necked round bottomed flask equipped with a magnetic stirrer, nitrogensweep and addition funnel was charged with anhydrous dichloromethane (100 mL) and sodium (0.3mol, 6.9 g). A freshly distilled diethylphosphite (0.3 mol, 40 g) was added dropwise at 0°C over 2hours with continuous stirring at 0°C for 48 hours. Then, the reaction the reaction was vigorouslystirred at room temperature for 12 days under nitrogen atmosphere. The obtained blue reaction mixturewas diluted with water (20 mL) and extracted with CHCl3 (3 x 25 mL). The organic layers were driedover Na2SO4 and concentrated under vacuum. The residue was distilled under reduced pressure to provide the tetraethyl methylenediphosphonate 1 in a comparable yield (25 g, 58 %) to that reported byHormi and co-workers.
References:
Yahyaoui, Marwa;Touil, Soufiane;Samarat, Ali [Chemistry Letters,2018,vol. 47,# 6,p. 729 - 731] Location in patent:supporting information
75-09-2
1279 suppliers
$10.00/25ML
762-04-9
343 suppliers
$10.00/10g
1660-94-2
199 suppliers
$10.00/1g
1499-29-2
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$140.00/1g
64-17-5
856 suppliers
$10.00/50g
1660-94-2
199 suppliers
$10.00/1g
