Yield:128312-58-3 67%

Reaction Conditions:

in methanol; for 2 h;Reflux;Hantzsch Thiazole Synthesis;

Steps:

Synthesis of cyclopropylthiazoles.

General procedure: A solution of halo ketone 1a-c (27 mmol) and thioamide (27 mmol) in 100 ml of methanol was heated to reflux for 2 h for bromo ketones or 10 h for chloro ketones. The solvent was removed in vacuo, the residue was treated with 100 ml of saturated NaHCO3 solution and extracted with chloroform (3 × 70 ml). The combined organic layer was dried over anhydrous MgSO4 and evaporated in vacuoto give the crude product, which was additionally purified by flash columnchromatography.

References:

Tomilov, Yury V.;Salikov, Rinat F.;Platonov, Dmitry N.;Lipilin, Dmitry L.;Frumkin, Aleksandr E. [Mendeleev Communications,2013,vol. 23,# 1,p. 22 - 23]