Thiazole-5-carboxylic acid synthesis
- Product Name:Thiazole-5-carboxylic acid
- CAS Number:14527-41-4
- Molecular formula:C4H3NO2S
- Molecular Weight:129.14
Thiazole-5-carboxylic acid can be used as organic intermediate and pharmaceutical intermediate, mainly in laboratory research and development process. It can be synthesized by the hydrolysis reaction of Ethyl thiazole-5-carboxylate.
79265-30-8
188 suppliers
$22.00/1g
14527-41-4
215 suppliers
$8.00/250mg
Yield:-
Reaction Conditions:
with n-butyllithium in hexane
Steps:
a (a)
(a) 5-Thiazolecarboxylic acid 2-(Trimethylsilyl)thiazole (2 g, 12.7 mmol) in ether (10 ml) was added dropwise to a solution of n-butyllithium (1.43M in hexane, 9.33 ml) in ether (20 ml) over 20 min. at -78° C., stirred for 1 h and quenched with solid carbon dioxide. The mixture was allowed to warm to room temperature over 16 h, diluted with 10% sodium hydroxide and extracted twice with ethyl acetate. The aqueous layer was acidified with ice-cold dilute HCl, extracted with ethyl acetate, the organic extract washed with brine, dried over sodium sulphate and evaporated to give a pale yellow solid (870 mg), 1H NMR (d6 -DMSO) 13.58 (1H, br. s), 9.33 (1H, s), 8.45 (1H, s).
References:
Astra Pharmaceuticals Limited US5883102, 1999, A
288-47-1
300 suppliers
$6.00/1g
124-38-9
724 suppliers
$175.00/23402
14527-41-4
215 suppliers
$8.00/250mg
14190-59-1
196 suppliers
$15.00/1g
32955-22-9
133 suppliers
$8.00/250mg
14527-41-4
215 suppliers
$8.00/250mg
3034-55-7
217 suppliers
$7.00/250mg
14527-41-4
215 suppliers
$8.00/250mg