Tiotropium Bromide Monohydrate synthesis
- Product Name:Tiotropium Bromide Monohydrate
- CAS Number:139404-48-1
- Molecular formula:C19H22BrNO4S2.H2O
- Molecular Weight:490.43
136310-64-0
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74-83-9
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139404-48-1
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$39.00/10mg
Yield:139404-48-1 98%
Reaction Conditions:
in N,N-dimethyl-formamide at 20; for 16 h;Large scale;
Steps:
6 Preparation of tiotropium bromide from N-demethyl-tiotropium
3.6 kg N-demethyl tiotropium was dissolved in 10 L DMF and 2 L methyl bromide was added to the mixture. It was stirred at room temperature for 16 h. The reaction mixture was cooled to 10 °C and diethyl ether was added. Product crystals were filtered and washed with diethyl ether. Wet product was dried under vacuum at 45 °C for 2 h to afford anhydrous tiotropium bromide (4.4 kg of dry product; yield: 98%, HPLC purity: 99.9%)
References:
WO2021/133280,2021,A1 Location in patent:Page/Page column 15
![3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-[(2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide (1:1), (1α,2β,4β,5α,7β)-](/CAS/20200331/GIF/1336913-22-4.gif)
1336913-22-4
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139404-48-1
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$39.00/10mg
1374772-94-7
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1508-46-9
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$490.00/10mg
139404-48-1
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26447-85-8
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155-41-9
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139404-48-1
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$39.00/10mg
411207-31-3
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$218.00/y0001188
139404-48-1
270 suppliers
$39.00/10mg