一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Triethylenethiophosphoramide
52-24-4

Triethylenethiophosphoramide synthesis

1synthesis methods
Thiotepa, tris(1-aziridinyl)phosphine sulfate (30.2.2.1), is made by reacting ethylenimine with phosphorous sulfochloride .

-

Yield:52-24-4 90.7%

Reaction Conditions:

with trichlorothiophosphine at 16.5; for 0.533333 h;Temperature;

Steps:

1; 2; 3
S1: Ethyleneimine and 870 mL of organic solvent was added to the low temperature reactor, the refrigerant interlayer was turned on to pass the cold, circulation cooling, when the temperature in the reactor drops to 16.5 ° C, the stirring paddle was turned on;S2: The Thiophosphoryl chloride dissolved in an organic solvent 1690mL, and was added drop wise to the reaction kettle, when thiophosphoryl chloride organic solvent was added dropwise to 828.1 mL, the predetermined amount of thiophosphoryl chloride was added= =0 =0.49 mol / 1 mol = 49%, the acid binding agent is added drop wise, the dropping rate of the acid binding agent was 3.06 times of the dropping rate of the organic solvent thiophosphoryl chloride, and the reaction temperature was maintained at 16.5 ° C for 32 min;S3: Filtered, the filtrate solvent was evaporated under reduced pressure to obtain an organic residue , the residue was dissolved in ethyl acetate, Cyclohexane was added under stirring, stirring was continued, the solution was passed at -7 ° C, crystallized, suction filtered, and dried to obtain 171.5 g of thiotepa, yield was 90.7%, the purity was 99.3%, and the solid-liquid ratio of the residue and ethyl acetate was 1 g: 11 mL, the volume ratio of ethyl acetate to cyclohexane was 11:18.5.

References:

Heilongjiang Fuhe Pharmaceutical Group Co., Ltd.;Wu Guangyan CN108484669, 2018, A Location in patent:Paragraph 0031; 0034-0036; 0037; 0040-0042; 0043; 0046-0048

FullText

Triethylenethiophosphoramide Related Search:

衢州市| 黔西县| 荆州市| 雅江县| 昌黎县| 灵石县| 金寨县| 黑水县| 登封市| 淮滨县| 富阳市| 蒙山县| 乡宁县| 吉安市| 清远市| 苏尼特左旗| 南江县| 彝良县| 盐城市| 逊克县| 商洛市| 柘城县| 祁阳县| 扶风县| 仙居县| 梁山县| 长垣县| 余庆县| 息烽县| 嵩明县| 涿鹿县| 晋城| 郧西县| 临泉县| 宁德市| 新化县| 嵊泗县| 巧家县| 遂宁市| 高陵县| 黄浦区|