Warfarin synthesis
- Product Name:Warfarin
- CAS Number:81-81-2
- Molecular formula:C19H16O4
- Molecular Weight:308.33
1076-38-6
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$24.00/100 g
60-12-8
619 suppliers
$6.00/25g
516-06-3
345 suppliers
$8.00/25g
81-81-2
187 suppliers
$18.00/1g
Yield:81-81-2 84%
Reaction Conditions:
in dimethyl sulfoxide at 20; for 16 h;
Steps:
1.1.1 1. Synthesis of Compound 3
4-hydroxycoumarin (compound 1, 1.62 g, 10 mmol),Benzylmethanol (Compound 2, 1.46 mg, 10 mmol)A solution of DL-valine (580 mg, 5 mmol) in DMSO (20 mL) was stirred at 20 ° C for 16 h.120 mL of water was added to the reaction mixture.The reaction mixture was extracted three times with ethyl acetate (100 mL).The combined organic phases were washed with 100 mL of water and brine (100 mL)The solvent was recovered on a rotary evaporator to give a white residue (3.3 g).The residue was separated by silica gel column chromatography ( petroleum ether: ethyl acetate = 4:1, v/v)A white powder (2.60 g, 84%) was obtained as Compound 3.
References:
China Agricultural University;Shen Jianzhong;Wang Zhanhui;Jiang Haiyang;Wen Kai;Yu Wenbo;Yu Xuezhi;Li Hongfang;Duan Changfei;Shi Weimin;Zhang Suxia CN109824645, 2019, A Location in patent:Paragraph 0060; 0061-0063
1076-38-6
558 suppliers
$24.00/100 g
122-57-6
437 suppliers
$5.00/25g
81-81-2
187 suppliers
$18.00/1g
1076-38-6
558 suppliers
$24.00/100 g
1896-62-4
233 suppliers
$11.00/100g
81-81-2
187 suppliers
$18.00/1g
100-52-7
977 suppliers
$17.30/2g
81-81-2
187 suppliers
$18.00/1g
100-51-6
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$5.00/100g
81-81-2
187 suppliers
$18.00/1g