| Hazard Information | Back Directory | [Uses]
α-Synuclein inhibitor 8 is an active inhibitor of α-Synuclein with an IC50 value of 2.5 μM. α-Synuclein inhibitor 8 has highly inhibition on the aggregation and disaggregation of α-Synuclein fibers. α-Synuclein inhibitor 8 reduces the formation of inclusions in neurons that can repairs damage neurons and improves Parkinson’s disease (PD)-like symptoms. α-Synuclein inhibitor 8 has high antioxidant activity and low cytotoxicity[1]. | [in vivo]
α-Synuclein inhibitor 8 (Compound 2ee) (0.9 μg/μL; i.v.; single dose) significantly improves Parkinson’s disease (PD)-like symptoms such as weak grip, limb stiffness and poor balance in C57 mice model of PD. α-Synuclein inhibitor 8 has neuroprotective effect on the middle caudate putamen (CPU) and substantia nigra reticular (SNr) of the brain in C57 mice model of PD[1]. | Animal Model: | 6-OHDA-lesioned C57 mice model of PD (8-12 weeks, 20-28 g)[1]. | | Dosage: | 0.9 μg/μL. | | Administration: | Intravenous injection (right striatum); single dose. | | Result: | Exhibited neuroprotective and repair effects. |
| [IC 50]
α-synuclein Aggregation | [References]
[1] Lü MH, et al. Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice. Eur J Med Chem. 2023 Jan 18;249:115122. DOI:10.1016/j.ejmech.2023.115122 |
|
|