| Identification | Back Directory | [Name]
2,6-Piperidinedione, 3-(3-bromo-2-chlorophenyl)- | [CAS]
3050687-70-9 | [Synonyms]
CRBN ligand-13
3-(3-Bromo-2-chlorophenyl)piperidine-2,6-dione
2,6-Piperidinedione, 3-(3-bromo-2-chlorophenyl)- | [Molecular Formula]
C11H9BrClNO2 | [MOL File]
3050687-70-9.mol | [Molecular Weight]
302.55 |
| Chemical Properties | Back Directory | [Boiling point ]
445.1±45.0 °C(predicted) | [density ]
1.611±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Store at room temperature | [form ]
Powder | [pka]
10.97±0.40(predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C11H9BrClNO2/c12-8-3-1-2-6(10(8)13)7-4-5-9(15)14-11(7)16/h1-3,7H,4-5H2,(H,14,15,16) | [InChIKey]
ALZZHOGCXUFQPV-UHFFFAOYSA-N | [SMILES]
O=C1NC(CCC1C1C=CC=C(C=1Cl)Br)=O |
| Hazard Information | Back Directory | [Uses]
CRBN ligand-13 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC. | [IC 50]
Cereblon | [References]
[1] Mileti? N, et al. Workflow for E3 Ligase Ligand Validation for PROTAC Development. ACS Chem Biol. 2025 Feb 21;20(2):507-521. DOI:10.1021/acschembio.4c00812 |
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