| Identification | Back Directory | [Name]
C18 L-threo Ceramide (d18:1/18:0) | [CAS]
95037-06-2 | [Synonyms]
Octadecanoyl-L-threo-sphingosine
C18 L-threo Ceramide (d18:1/18:0) | [Molecular Formula]
C36H71NO3 | [MOL File]
95037-06-2.mol | [Molecular Weight]
565.95 |
| Chemical Properties | Back Directory | [Boiling point ]
694.5±55.0 °C(Predicted) | [density ]
0.915±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
A solid | [pka]
13.54±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids.1 It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 8.8 μM.2 | [Uses]
Octadecanoyl-L-threo-sphingosine is an ester product. | [storage]
Store at -20°C | [References]
1. Sarmientos, F., Schwarzmann, G., and Sandhoff, K. Direct evidence by carbon-13 NMR spectroscopy for the erythro configuration of the sphingoid moiety in Gaucher cerebroside and other natural sphingolipids Eur. J. Biochem. 146(1),59-64(1985).
2. Usta, J., El Bawab, S., Roddy, P., et al. Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase Biochemistry 40(32),9657-9668(2001). |
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