103057-44-9
103057-44-9 結(jié)構(gòu)式
基本信息
1-叔丁氧羰基-3-羥基吡咯烷
(R)-1-BOC-3-羥基吡咯烷
(R)-1-叔丁氧羰基-3-羥基吡咯烷
1-BOC-羥基吡咯烷
(±)-1-BOC-3-羥基吡咯烷,97%
1-N-BOC-3-HYDROXY-PYRROLIDINE
3-HYDROXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
N-BOC-3-HYDROXYPYRROLIDINE
N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE
Tert-butyl 3-hydroxypyrrolidine-1-carboxylate
(S) 1-BOC-3-hydroxylpyrrolidine
3-Hydroxypyrrolidine, N-BOC protected
Tert-butyl 3-hydroxypyrrolidinecarboxylate
N-boc-3-Pyrrolidinol
(R)-1-Boc-3-hydroxypyrrolidine
(R)-3-Hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
(R)-N-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine
DL-1-BOC-3-HYDROXY-PYRROLIDINE
-BOC-3-HYDROXYPYRROLIDINE
(r)-1-boc-3-hydroxypyrrolidineester
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
toxic compounds or compounds which causing chronic effects
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
制備方法
24424-99-5
40499-83-0
83220-73-9
以二碳酸二叔丁酯和3-羥基吡咯烷為原料，合成1-叔丁氧基羰基-3-羥基-吡咯烷的一般步驟如下：首先，將(R)-3-吡咯烷醇（539 mg，6.19 mmol）轉(zhuǎn)化為化合物16b，得到無(wú)色油狀物（1.3 g，產(chǎn)率100%）。該化合物的光譜數(shù)據(jù)與預(yù)期結(jié)構(gòu)一致，并與文獻(xiàn)報(bào)道相符（參見(jiàn)Kucznierz, R.等人，J. Med. Chem. 1998, 41, 4983-4994）。隨后，化合物16b經(jīng)過(guò)反應(yīng)轉(zhuǎn)化為化合物16c，同樣為無(wú)色油狀物。接著，通過(guò)兩步反應(yīng)將化合物16c轉(zhuǎn)化為化合物16e，仍為無(wú)色油狀物。最后，化合物16e經(jīng)過(guò)反應(yīng)生成目標(biāo)化合物16，呈現(xiàn)為黃色油狀物。
參考文獻(xiàn)：
[1] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 969 - 973
[2] Patent: WO2015/9731, 2015, A2. Location in patent: Paragraph 00106
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4983 - 4994
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 17, p. 5812 - 5832
[5] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 86
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/07/06 | H28750 | (+/-)-1-Boc-3-羥基吡咯烷,97% (±)-1-Boc-3-hydroxypyrrolidine, 97% | 103057-44-9 | 25g | 2755元 |
| 2026/06/06 | B3603 | 1-(叔丁氧羰基)-3-吡咯烷醇 1-(tert-Butoxycarbonyl)-3-pyrrolidinol | 103057-44-9 | 5g | 30元 |
| 2026/06/06 | B3603 | 1-(叔丁氧羰基)-3-吡咯烷醇 1-(tert-Butoxycarbonyl)-3-pyrrolidinol | 103057-44-9 | 25g | 110元 |