104060-23-3
104060-23-3 結(jié)構(gòu)式
基本信息
N-BOC-2-(4-氨基苯基)乙醇
2-[4-(Boc-amino)phenyl]ethanol
N-Boc-2-(4-aminophenyl)ethanol
tert-Butyl (4-(2-hydroxyethyl)phenyl)carbamate
tert-butyl N-[4-(2-hydroxyethyl)phenyl]carbamate
Carbamic acid, N-[4-(2-hydroxyethyl)phenyl]-, 1,1-dimethylethyl ester
制備方法
24424-99-5
104-10-9
104060-23-3
步驟1. 制備4-(2-羥基乙基)苯基氨基甲酸叔丁酯: 向2-(4-氨基苯基)乙醇(1g, 7.28mmol)的乙酸乙酯(10ml)溶液中加入二碳酸二叔丁酯(1.75g, 8.01mmol)。反應(yīng)混合物在室溫下攪拌24小時。反應(yīng)完成后，向反應(yīng)混合物中加入水和乙酸乙酯進行萃取。有機層用無水硫酸鎂干燥，隨后減壓除去溶劑。通過柱色譜法(正己烷:乙酸乙酯=1:2)純化殘余物，得到1.72g(產(chǎn)率:99%，白色固體)N-Boc-2-(4-氨基苯基)乙醇。1H NMR(400MHz, CDCl3): δ7.29(d, J=8.4Hz, 2H), 7.16(d, J=8.4Hz, 2H), 6.45(br s, 1H), 3.82(br s, 2H), 2.81(t, J=6.6Hz, 2H), 1.52(s, 9H)。
參考文獻：
[1] Medicinal Chemistry Research, 2003, vol. 11, # 7, p. 380 - 398
[2] Patent: WO2009/61131, 2009, A2. Location in patent: Page/Page column 50
[3] Patent: WO2004/65402, 2004, A1. Location in patent: Page/Page column 148-149
[4] Patent: US6362360, 2002, B1. Location in patent: Example 1
[5] Patent: US2003/18207, 2003, A1