一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>113906-27-7

113906-27-7

中文名稱 PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE
英文名稱 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
CAS 113906-27-7
分子式 C19H16N2O3
分子量 320.34
MOL 文件 113906-27-7.mol
更新日期 2023/03/20 15:41:29
113906-27-7 結(jié)構(gòu)式 113906-27-7 結(jié)構(gòu)式

基本信息

中文別名
WNT/Β-CATENIN通路抑制劑(PNU-74654)
英文別名
CS-2563
PNU 74654
PNU74654
PNU 74654
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide
PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide

物理化學(xué)性質(zhì)

密度1.17±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度二甲基亞砜:>10mg/mL
酸度系數(shù)(pKa)12.12±0.46(Predicted)
形態(tài)固體
顏色白色至灰白色
穩(wěn)定性自購買之日起 1 年內(nèi)保持穩(wěn)定。 DMSO 中的溶液可在 -20° 下保存長(zhǎng)達(dá) 3 個(gè)月。
InChI1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+
InChIKeyJJEDWBQZCRESJL-DEDYPNTBSA-N
SMILESCc1ccc(\C=N\NC(=O)c2ccccc2Oc3ccccc3)o1

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)有害 (GHS07)
GHS07
警示詞警告
危險(xiǎn)性描述H302
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼22
WGK Germany3
存儲(chǔ)類別11 - Combustible Solids
危險(xiǎn)性類別Acute Tox. 4 Oral
PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-101130PNU-74654113906-27-71 mg212元
2026/06/05HY-101130PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE
PNU-74654
113906-27-75mg530元
2026/06/05HY-101130PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE
PNU-74654
113906-27-710mM * 1mLin DMSO583元

常見問題列表

生物活性
PNU-74654是Wnt/β-catenin通路的的抑制劑,在NCI-H295 細(xì)胞中的IC50值為129.8 μM。
靶點(diǎn)

129.8 μM (Wnt/β-catenin, NCI-H295 cell)

體外研究

PNU-74654 binds to β-catenin with a K D of 450 nM. The Tcf3/Tcf4-binding surface on β-catenin contains a well-defined hot spot around residues K435 and R469. The binding mode of PNU-74654 involves the two narrow pockets on either side of this hot spot. In NCI-H295 cells,PNU-74654 significantly decreases cell proliferation 96 h after treatment, increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impairs CTNNB1/beta-catenin expression and increases beta-catenin target genes 48 h after treatment. No effects are observed on HeLa cells. In NCI-H295 cells, PNU-74654 decreases cortisol, testosterone and androstenedione secretion 24 and 48 h after treatment. The SF1 and CYP21A2 mRNA expression as well as the protein levels of STAR and aldosterone synthase are decreased in NCI-H295 cells after 48 h PNU-74654 treatment. In Y1 cells, PNU-74654 impairs corticosterone secretion 24 h after treatment but does not decrease cell viability.

"113906-27-7" 相關(guān)產(chǎn)品信息
1268524-70-4 1268524-69-1 331458-02-7 220904-83-6 128311-08-0 737727-12-7
连州市| 屯昌县| 普兰店市| 靖江市| 海城市| 平舆县| 越西县| 伊通| 崇阳县| 四川省| 崇信县| 温州市| 长宁区| 绍兴市| 沂水县| 潮安县| 大足县| 邵阳市| 茶陵县| 临邑县| 郴州市| 南康市| 葫芦岛市| 江北区| 玛沁县| 股票| 灵寿县| 新和县| 永川市| 长岛县| 通化县| 阜城县| 周至县| 黑水县| 金乡县| 吉林省| 靖远县| 桂东县| 临朐县| 绿春县| 汝城县|