132836-42-1

中文名稱 1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇氫溴酸鹽

英文名稱 YS 49

CAS 132836-42-1

分子式 C20H20BrNO2

分子量 386.282

MOL 文件 132836-42-1.mol

更新日期 2024/12/03 15:40:38

132836-42-1 結(jié)構式

基本信息物理化學性質(zhì) 安全數(shù)據(jù) 圖譜信息 1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇氫溴酸鹽價格(試劑級) 常見問題列表

基本信息

中文別名

1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇氫溴酸鹽

英文別名

YS 49
CS-884
YS 49
YS49
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate

所屬類別

生物化工：激動劑抑制劑

物理化學性質(zhì)

儲存條件2-8°C

溶解度H2O：>10mg/mL

形態(tài)固體

顏色White to off-white

水溶解性H2O: >10mg/mL

InChI1S/C20H19NO2.BrH.H2O/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14;;/h1-7,11-12,18,21-23H,8-10H2;1H;1H2

InChIKeyQHCUNMLYODPTIU-UHFFFAOYSA-N

SMILESO.Br.Oc1cc2CCNC(Cc3cccc4ccccc34)c2cc1O

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H302

危險品標志Xn,N

危險類別碼22-50

安全說明61

危險品運輸編號UN 3077 9 / PGIII

WGK Germany3

存儲類別11 - Combustible Solids

危險性類別Acute Tox. 4 Oral

圖譜信息

1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇氫溴酸鹽(132836-42-1)核磁圖(¹HNMR)

1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇氫溴酸鹽價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-15477	1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇氫溴酸鹽 YS-49	132836-42-1	1 mg	348元
2026/06/05	HY-15477	1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇氫溴酸鹽 YS-49	132836-42-1	5 mg	767元
2026/06/05	HY-15477	1,2,3,4-四氫-1-(1-萘基甲基)-6,7-異喹啉二醇氫溴酸鹽 YS-49	132836-42-1	10 mg	1228元

常見問題列表

生物活性

YS-49 是 PI3K/Akt (RhoA 的下游靶標) 的激活劑，可減少 3-甲基膽堿處理的細胞中 RhoA/PTEN 的激活。YS-49 能通過誘導血紅素加氧酶 (HO-1) 來抑制血管緊張素 II (Ang II) 刺激 VSMC 細胞的增殖。YS-49 是異喹啉化合物生物堿，因能激活心臟 β-adrenoceptors 而具有強烈的正性肌力作用。

體外研究

YS-49 (1-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC ₅₀ values of 22 μM and 30?μM, respectively.
YS-49 (10-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.

Cell Viability Assay

Cell Line:	RAVSMC and RAW 264.7 cells
Concentration:	10 μΜ, 30 μΜ and 100?μΜ (RAVSMC cells); 1 μΜ, 10 μΜ and 100?μM (RAW 264.7 cells)
Incubation Time:	18 hours
Result:	Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC ₅₀ values of 22 and 30?μM, respectively.

Western Blot Analysis

Cell Line:	RAVSMC and RAW 264.7 cells
Concentration:	10 μΜ, 30 μΜ and 100?μΜ
Incubation Time:	18 hours
Result:	Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ.

體內(nèi)研究

YS-49 (5?mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.

Animal Model:	Male Sprague Dawley rats (250-300?g)
Dosage:	5?mg/kg
Administration:	Intraperitoneal injection; 8 hours
Result:	Serum NOx levels were significantly reduced.