1335106-03-0

中文名稱 SR1001

英文名稱 SR 1001

CAS 1335106-03-0

分子式 C15H13F6N3O4S2

分子量 477.4

MOL 文件 1335106-03-0.mol

更新日期 2024/05/20 09:19:55

1335106-03-0 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 SR1001價格(試劑級) 常見問題列表

基本信息

中文別名

化合物SR1001

英文別名

SR 1001
SR-1001
SR 1001
SR1001 >=98% (HPLC)
N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide
N-(5-{[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]sulfamoyl}-4-methyl-1,3-thiazol-2-yl)acetamide
N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide
SR1001,N-{4-Methyl-5-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenylsulfaMoyl]-thiazol-2-yl}-acetaMide
Acetamide, N-[4-methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolyl]-

所屬類別

生物化工：激動劑抑制劑

物理化學(xué)性質(zhì)

密度1.640±0.06 g/cm3(Predicted)

儲存條件Sealed in dry,2-8°C

溶解度二甲基亞砜：>5mg/mL

酸度系數(shù)(pKa)5.90±0.50(Predicted)

形態(tài)粉末

顏色白色至米色

穩(wěn)定性可在-20°下的DMSO中的溶液保存長達(dá)3個月。

InChI1S/C15H13F6N3O4S2/c1-7-11(29-12(22-7)23-8(2)25)30(27,28)24-10-5-3-9(4-6-10)13(26,14(16,17)18)15(19,20)21/h3-6,24,26H,1-2H3,(H,22,23,25)

InChIKeyOZBSSKGBKHOLGA-UHFFFAOYSA-N

SMILESCC(=O)Nc1nc(C)c(s1)S(=O)(=O)Nc2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H302-H319

防范說明P264-P270-P280-P301+P312-P305+P351+P338-P337+P313

危險(xiǎn)品標(biāo)志Xn

危險(xiǎn)類別碼22-36

安全說明26

WGK Germany3

存儲類別11 - Combustible Solids

危險(xiǎn)性類別Acute Tox. 4 Oral
Eye Irrit. 2

圖譜信息

SR1001(1335106-03-0)核磁圖(¹HNMR)

SR1001價格(試劑級)

報(bào)價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-13421R	SR1001 SR1001 (Standard)	1335106-03-0	5 mg	1540元
2026/06/05	HY-13421R	SR1001 SR1001 (Standard)	1335106-03-0	10 mg	2520元
2026/06/05	HY-13421	SR1001	1335106-03-0	1 mg	304元

常見問題列表

生物活性

SR1001是RORα的反向激動劑，對RORα和RORγ的Ki值分別為172 nM和111 nM。

靶點(diǎn)

Target	Value
RORγ ()	111 nM(Ki)
RORα ()	172 nM(Ki)

體外研究

SR1001 inhibits the development of murine T _H 17 cells by inhibition of IL-17A gene expression and protein production. SR1001 reduces the interaction of a coactivator TRAP220 NR box 2 peptide with ROR _γ in a dose dependent manner (IC ₅₀ value≈117 nM). Additionally, SR1001 inhibits the expression of cytokines when added to differentiated murine or human T _H 17 cells.

體內(nèi)研究

SR1001 effectively suppresses the clinical severity of autoimmune disease in mice. Administration of SR1001 to C57BL/6 mice suppresses the expression of hepatic ROR target genes, Cyp7b1, Rev-erbα, and Serpine 1. SR1001 a ROR _α inverse agonist eliminats the circadian pattern of expression of citrate synthase mRNA in mice.