1337482-17-3
中文名稱
索菲布韋雜質(zhì)
英文名稱
L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine
CAS
1337482-17-3
分子式
C34H45FN4O13P2
分子量
798.69
MOL 文件
1337482-17-3.mol
更新日期
2025/11/03 09:39:45
1337482-17-3 結(jié)構(gòu)式
基本信息
中文別名
索非布韋雜質(zhì)F索菲布韋雜質(zhì)F
索福斯布韋雜質(zhì)5
索非布韋雜質(zhì)09
英文別名
Sofosbuvir 3'Sofosbuvir Dimer
5'-Bis-(S)-phosphate
Sofosbuvir impurity F
Sofosbuvir 3’,5’-Bis-(S)-phosphate
L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine
isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosph
isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alanite
isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alaninate
(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)amino)propanoate
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
密度1.37±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)9.39±0.10(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
常見問題列表
概述
索菲布韋雜質(zhì) 是 Sofosbuvir 的非對映異構(gòu)體，是 Sofosbuvir 的雜質(zhì)。Sofosbuvir (PSI-7977) 是 HCV RNA復(fù)制的抑制劑，表現(xiàn)出有效的抗丙型肝炎病毒活性。