136676-91-0
中文名稱
PD 123319 二(三氟乙酸鹽)
英文名稱
S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt
CAS
136676-91-0
分子式
C33H33F3N4O5
分子量
622.65
MOL 文件
136676-91-0.mol
更新日期
2024/07/24 18:26:21
136676-91-0 結(jié)構(gòu)式
基本信息
中文別名
PD 123319 二(三氟乙酸鹽) 英文別名
PD 123319 bis(trifluoroacetate)PD 123319 (trifluoroacetate salt)
PD123319
PD-123319
S-+-PD 123319
PD 123319 DITRIFLUOROACETATE, CID: 6604951
PD 123,319 di(trifluoroacetate) salt hydrate
PD 123,319 hydrate di(trifluoroacetate) salt
PD 123,319 di(trifluoroacetate) salt hydrate powder, >=98% (HPLC)
(S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid bis(trifluoroacetate)
S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate
S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt
物理化學(xué)性質(zhì)
儲存條件2-8°C
溶解度在水中的溶解度為10mg/mL，澄清
形態(tài)粉末
顏色White to yellow
水溶解性溶于水至100mM
InChIKeyPTSUEYBWHKDYBS-FPCIESGBSA-N
SMILESO.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CN(C)c1ccc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C(c4ccccc4)c5ccccc5)cc1C
安全數(shù)據(jù)
警示詞警告
危險性描述H315-H319-H335
危險品標志Xi
危險類別碼36/37/38
安全說明26
WGK Germany3
存儲類別11 - Combustible Solids
危險性類別Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Skin Irrit. 2
STOT SE 3
PD 123319 二(三氟乙酸鹽)價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-10259A | PD 123319 二(三氟乙酸鹽) PD 123319 ditrifluoroacetate | 136676-91-0 | 1 mg | 405元 |
| 2026/06/05 | HY-10259A | PD 123319 二(三氟乙酸鹽) PD 123319 ditrifluoroacetate | 136676-91-0 | 5 mg | 893元 |
| 2026/06/05 | HY-10259A | PD 123319 二(三氟乙酸鹽) PD 123319 ditrifluoroacetate | 136676-91-0 | 10 mg | 1116元 |
常見問題列表
生物活性
PD 123319 ditrifluoroacetate 是一種有效的，選擇性的 AT2 angiotensin II receptor 拮抗劑，IC50 值為 34 nM。靶點
IC50: 34 nM (AT2 Receptor)
體外研究
PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125 I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC 50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125 I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC 50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC 50 around 10 microM).