146986-50-7

中文名稱 Y-27632二鹽酸鹽

英文名稱 Y-27632 DIHYDROCHLORIDE

CAS 146986-50-7

分子式 C14H21N3O

分子量 247.34

MOL 文件 146986-50-7.mol

更新日期 2026/05/26 12:43:16

146986-50-7 結構式

基本信息物理化學性質安全數(shù)據(jù) 圖譜信息 Y-27632價格(試劑級) 常見問題列表

基本信息

中文別名

Y-27632二鹽酸鹽
ROCK-I和ROCK-II抑制劑
ROCK抑制劑(AZAINDOLE1)
ROCK-I和ROCK-II抑制劑(Y-27632)
反式-4-(R-1-氨基乙基)-N-(吡啶-4-基)環(huán)己烷甲酰胺
4-[(1R)-1-氨基乙基]-N-(吡啶-4-基)環(huán)己烷-1-甲酰胺
4-[(1R)-1-氨基乙基]-N-(吡啶-4-基)環(huán)己烷-1-甲酰胺二鹽酸鹽

英文別名

CS-20
Y-27632
Y-276322HCl
ROCK INHIBITOR
Y-27632/Y27632
Y-27632 (2HCl),98%
Y-27632, free base
Y-27632 DIHYDROCHLORIDE
Y-27632, Free Base, >99%
4-[(1R)-1-Aminoethyl]-N-(4-pyridinyl)cyclohexanecarboxamide

所屬類別

生物化工：激動劑抑制劑

物理化學性質

熔點>260°C (dec.)

沸點462.6±15.0 °C(Predicted)

密度1.136±0.06 g/cm3(Predicted)

儲存條件Keep in dark place,Sealed in dry,2-8°C

溶解度H₂O: 14 mg/mL

酸度系數(shù)(pKa)13.53±0.40(Predicted)

形態(tài)solid

顏色white

穩(wěn)定性吸濕性

InChIInChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1

InChIKeyIYOZTVGMEWJPKR-IJLUTSLNSA-N

SMILES[C@@H]1(C(NC2C=CN=CC=2)=O)CC[C@@H]([C@H](N)C)CC1

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H302-H312-H332

防范說明P280

危險品標志Xn

危險類別碼20/21/22

安全說明36

WGK Germany3

圖譜信息

Y-27632二鹽酸鹽(146986-50-7)核磁圖(¹HNMR)

Y-27632價格(試劑級)

報價日期	產品編號	產品名稱	CAS號	包裝	價格
2025/12/22	HY-10583	Y-27632二鹽酸鹽 Y-27632 dihydrochloride	146986-50-7	2 mg	450元
2025/12/22	HY-10583	Y-27632二鹽酸鹽 Y-27632 dihydrochloride	146986-50-7	5mg	700元
2025/12/22	HY-10583	Y-27632二鹽酸鹽 Y-27632 dihydrochloride	146986-50-7	10mM * 1mLin DMSO	770元

常見問題列表

生物活性

Y-27632 是口服有效的， ATP 競爭性的 ROCK-I 和 ROCK-II 抑制劑，Ki 分別為 220 nM 和 300 nM。Y-27632 誘導凋亡 (apoptosis)。Y-27632 通過上皮-間充質過渡樣調節(jié)引發(fā)人誘導多能干細胞 (hIPSCs) 選擇性地分化為間胚層譜系。

靶點

ROCK-I

220 nM (Ki)

ROCK-II

300 nM (Ki)

PKN

3.1 μM (Ki)

Citron kinase

5.3 μM (Ki)

PKCα

73 μM (Ki)

PKA

25 μM (Ki)

體外研究

Y-27632 inhibits the ROCK family of kinases 100 times more potently than other kinases including protein kinase C, cAMP-dependent kinase and myosin light chain kinase. Y-27632 prolongs the lag time and delays the appearance of BrdU-labeled cells in a concentration-dependent manner, delays of about 1 and 4 h are noticed in the Swiss 3T3 cells treated with 10 and 100 μM Y-27632, respectively. Y-27632 promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs). Compared to 1.0 and 2.5 μM Y-27632 induced groups, percentages of neuroal-like cells achieved a peak in the 5.0 μM Y-27632 induced group.

體內研究

Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group).