15917-65-4
中文名稱
N-去甲基三苯氧胺 鹽酸鹽
英文名稱
N-Desmethyl Tamoxifen Hydrochloride
CAS
15917-65-4
分子式
C25H27NO.ClH
分子量
393.955
MOL 文件
15917-65-4.mol
更新日期
2026/06/02 17:46:08
15917-65-4 結(jié)構(gòu)式
基本信息
中文別名
N-去甲基三苯氧胺 鹽酸鹽N-去甲基三苯氧胺 鹽酸鹽/N-去甲基他莫昔芬鹽酸鹽
2-[4-[(1Z)-1,2-二苯基-1-丁烯基]苯氧基]-N-甲基乙胺鹽酸鹽
英文別名
Nsc372964N-Demethyltamoxifen Hydrochlorid
(Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine
(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N-methylethanamine Hydrochloride
2-[4-[(1Z)-1,2-Diphenyl-1-butenyl]phenoxy]-N-methylethanamine hydrochloride
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
熔點(diǎn)225-227°C
儲(chǔ)存條件Amber Vial, -20°C Freezer
溶解度二甲基亞砜：≥20mg/mL
形態(tài)solid
顏色White to off-white
穩(wěn)定性Light sensitive
InChI1S/C25H27NO.ClH/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2;/h4-17,26H,3,18-19H2,1-2H3;1H/b25-24-;
InChIKeyGMLHJWZEYLTNJW-BJFQDICYSA-N
SMILESCl.CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCNC)cc3
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H350-H360-H410
防范說(shuō)明P202-P273-P280-P308+P313-P391-P405
危險(xiǎn)品標(biāo)志T,N
危險(xiǎn)類別碼45-46-60-50/53
安全說(shuō)明53-45-60-61
危險(xiǎn)品運(yùn)輸編號(hào)UN 3077 9 / PGIII
WGK Germany3
存儲(chǔ)類別6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
toxic compounds or compounds which causing chronic effects
危險(xiǎn)性類別Aquatic Acute 1
Aquatic Chronic 1
Carc. 1B
Repr. 1B
Aquatic Chronic 1
Carc. 1B
Repr. 1B
N-去甲基三苯氧胺 鹽酸鹽價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-129099A | N-去甲基三苯氧胺 鹽酸鹽 N-Desmethyltamoxifen hydrochloride | 15917-65-4 | 1 mg | 188元 |
| 2026/06/05 | HY-129099AR | N-去甲基三苯氧胺 鹽酸鹽 N-Desmethyltamoxifen hydrochloride (Standard) | 15917-65-4 | 1 mg | 1100元 |
| 2026/06/05 | HY-129099A | N-去甲基三苯氧胺 鹽酸鹽 N-Desmethyltamoxifen hydrochloride | 15917-65-4 | 5 mg | 380元 |
常見(jiàn)問(wèn)題列表
生物活性
N-Desmethyltamoxifen hydrochloride 是 Tamoxifen 在人體內(nèi)的主要代謝產(chǎn)物。N-Desmethyltamoxifen，較弱的抗雌激素，是一種比 Tamoxifen 強(qiáng)十倍的蛋白激酶 C (PKC) 抑制劑。N-Desmethyltamoxifen hydrochloride 也是人體 AML 細(xì)胞神經(jīng)酰胺代謝的有效調(diào)節(jié)因子，限制神經(jīng)酰胺糖基化、水解和鞘氨醇磷酸化。體外研究
N-desmethyltamoxifen hydrochloride (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
N-desmethyltamoxifen hydrochloride (1.5-10 μM; 114 hours) inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen hydrochloride, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen.
Cell Viability Assay
| Cell Line: | MCF 7 human mammary carcinoma cells |
| Concentration: | 1.5, 2.5, 5, 7.5, 10 μM |
| Incubation Time: | 114 hours |
| Result: | Inhibits growth of MCF 7 human mammary carcinoma cells |