170098-98-3
170098-98-3 結(jié)構(gòu)式
基本信息
1-溴-4-氟-2-甲基-5-硝基苯
2-Bromo-5-fluoro-4-nitrotoluene97%
2-Bromo-5-fluoro-4-nitrotoluene 97%
5-BroMo-2-fluoro-4-Methylnitrobenzene
4-Fluoro-2-methyl-5-nitrobromobenzene
1-Bromo-4-fluoro-2-methyl-5-nitrobenzene
Benzene, 1-bromo-4-fluoro-2-methyl-5-nitro-
1-Bromo-4-fluoro-2-methyl-5-nitrobenzene, 5-Bromo-2-fluoro-4-methylnitrobenzene
物理化學(xué)性質(zhì)
制備方法
452-63-1
170098-98-3
步驟1：硝化反應(yīng) 將2.21 g (16.7 mmol) 四氟硼酸硝鎓懸浮于30 mL二氯甲烷中。在回流條件下，緩慢滴加3.0 g (15.9 mmol) 2-溴-5-氟甲苯溶于30 mL二氯甲烷的溶液。滴加完畢后，繼續(xù)在回流條件下攪拌反應(yīng)混合物6小時。反應(yīng)完成后，將混合物倒入冰水中，用二氯甲烷萃取。合并有機相，用水洗滌，無水硫酸鈉干燥，隨后在旋轉(zhuǎn)蒸發(fā)儀上濃縮，得到黃色油狀物。靜置過夜，油狀物結(jié)晶。過濾收集晶體，用2 mL戊烷洗滌，干燥后得到265 mg (產(chǎn)率6.9%) 目標產(chǎn)物1-溴-4-氟-2-甲基-5-硝基苯。產(chǎn)物經(jīng)GC/MS分析（方法8，EIpos）：保留時間Rt = 4.49 min，質(zhì)荷比m/z = 232/234 [M]+。
參考文獻：
[1] Patent: WO2007/36718, 2007, A2. Location in patent: Page/Page column 57-58
[2] Patent: US2005/154020, 2005, A1. Location in patent: Page/Page column 8-9
[3] Patent: US2005/154022, 2005, A1. Location in patent: Page/Page column 9
[4] Patent: US2006/79523, 2006, A1. Location in patent: Page/Page column 13
[5] Patent: US2006/79524, 2006, A1. Location in patent: Page/Page column 13