一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>18444-66-1

18444-66-1

中文名稱 葫蘆素 E
英文名稱 Cucurbitacin E
CAS 18444-66-1
分子式 C32H44O8
分子量 556.69
MOL 文件 18444-66-1.mol
更新日期 2026/05/28 23:55:38
18444-66-1 結(jié)構(gòu)式 18444-66-1 結(jié)構(gòu)式

基本信息

中文別名
葫蘆苦素E
葫蘆素 E
葫蘆素E對照品
葫蘆素E(標(biāo)準(zhǔn)品)
葫蘆素E(葫蘆苦素E)
葫蘆素 E, >99%
葫蘆素 E, 來源于甜瓜
英文別名
25-acetate
A-ELATERIN
Cucurbit E
α-Elaterine
CUCURBITACIN E
ALPHA-ELATERIN
cucurbitacine-e
alpha-elaterine
CUCURBITACIN E(SH)
CUCURBITACIN E hplc
所屬類別
生物化工:中草藥成分

物理化學(xué)性質(zhì)

外觀性狀白色結(jié)晶粉末,可溶于甲醇、乙醇、DMSO等有機溶劑,來源于甜瓜蒂。
熔點228-234°C
比旋光度D -59° (c = 0.7 in chloroform)
沸點545.56°C (rough estimate)
密度1.1059 (rough estimate)
折射率1.4900 (estimate)
儲存條件-20°C
溶解度DMSO:可溶15mg/mL,澄清
酸度系數(shù)(pKa)8.51±0.70(Predicted)
形態(tài)粉末
顏色白色至米色
旋光度 (Optical Rotation)[α]/D -60 to -75°, c = 0.7 (CDCl3)
InChIKeyNDYMQXYDSVBNLL-MUYMLXPFSA-N
SMILES[C@@]12(C)C[C@@H](O)[C@]([H])([C@](O)(C)C(=O)/C=C/C(C)(C)OC(=O)C)[C@@]1(C)CC(=O)[C@@]1(C)[C@]3([H])C=C(C(=O)C(C)(C)C3=CC[C@@]21[H])O |&1:0,3,5,7,21,26,28,40,r|
LogP3.150 (est)

安全數(shù)據(jù)

危險性符號(GHS)有害 (GHS07)
GHS07
警示詞警告
危險性描述H302
防范說明P301+P312+P330
危險品標(biāo)志Xn
危險類別碼25-22
安全說明1-22-45-24/25
危險品運輸編號3172
WGK Germany3
RTECS號RC6305500
海關(guān)編碼29153900
毒性LD50 orally in mice: 340 mg/kg (Albert)

應(yīng)用領(lǐng)域

用途1
用于含量測定/鑒定/藥理實驗等。
藥理藥效:用于治療慢性肝炎。1細(xì)胞毒與抗癌作用,2抗肝損害,3提高機體免疫功能。
用途2
葫蘆素 E具有保肝,抗腫瘤(人體鼻咽癌),催吐,增強免疫的作用。
葫蘆素 E價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/12/22HY-N0417葫蘆素 E
Cucurbitacin E
18444-66-11 mg548元
2025/12/22HY-N0417葫蘆素 E
Cucurbitacin E
18444-66-15mg1200元
2025/12/22HY-N0417葫蘆素 E
Cucurbitacin E
18444-66-110mg1900元

常見問題列表

生物活性
Cucurbitacin E 是來自 Cucumic melo L 莖的一種天然化合物。Cucurbitacin E 顯著抑制 cyclin B1/CDC2 復(fù)合物的活性。
靶點

cyclin B1/CDC2

Autophagy

體外研究

To explore the antitumor activity of Cucurbitacin E (CuE) against colorectal cancer (CRC) cells, an in vitro study is initiated in which each of the CRC cell lines is exposed to increasing doses of Cucurbitacin E (0, 2.5, 5, and 7.5?μM) over a period of 24?h. The proliferation of the Cucurbitacin E-treated cancer cells is then measured using the MTT method. Cucurbitacin E is shown to induce morphological changes in the primary colon cancer cells. Microscopic observation showed that following exposure to Cucurbitacin E (5?μM) between 6 and 24?h, the primary colon cancer cells underwent a remarkable change in morphology. Cucurbitacin E inhibits tumor growth by arresting the cell cycle in the G 2 /M phase via GADD45γ gene expression and the blockage of cyclin B1/CDC2 complex in primary CRC cells.

體內(nèi)研究

A high fat diet mice model of metabolic syndrome (HFD-MetS) is developed to assess the role of Cucurbitacin E (CuE) on body weight and fat tissue biology. Significant decrease in body weights of HFD-MetS mice treated with Cucurbitacin E (0.5mg/kg) are found as compared to HFD-MetS mice treated with vehicle alone. Cucurbitacin E treatment reduces all fat pads weights in HFD-MetS mice. 55% reduction is observed in total fat in mice, after treatment with Cucurbitacin E in comparison to HFD-MetS mice. Abdominal obesity is strongly associated with metabolic syndrome. Central obesity is reduced to 50% after Cucurbitacin E treatment as compared to HFD MetS mice, elucidating the effectiveness of Cucurbitacin E in targeting MetS.

"18444-66-1" 相關(guān)產(chǎn)品信息
106-72-9 765-87-7
威远县| 中卫市| 明水县| 酉阳| 甘谷县| 隆德县| 页游| 保康县| 梅州市| 江阴市| 南川市| 长海县| 庐江县| 牟定县| 金平| 临江市| 隆安县| 岚皋县| 长春市| 吴川市| 高要市| 泸州市| 长沙市| 兴安县| 监利县| 温州市| 扶余县| 墨玉县| 柳州市| 农安县| 澎湖县| 呈贡县| 太湖县| 崇礼县| 乃东县| 衡山县| 措勤县| 奉贤区| 高要市| 德令哈市| 鹤山市|