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185055-67-8

中文名稱 二茂鐵氯喹
英文名稱 FERROQUINE
CAS 185055-67-8
分子式 C18H19ClN3.C5H5.Fe
分子量 433.762
MOL 文件 185055-67-8.mol
更新日期 2026/07/15 17:50:52
185055-67-8 結(jié)構(gòu)式 185055-67-8 結(jié)構(gòu)式

基本信息

中文別名
二茂鐵氯喹
英文別名
SSR 97193
FERROQUINE
Ferrochloroquine
7-Chloro-4-(((2-((dimethylamino)methyl)ferrocenyl)methyl)amino)quinoline

物理化學(xué)性質(zhì)

儲存條件-20°C儲存
溶解度DMSO : 8.33 mg/mL (19.20 mM)
形態(tài)Solid
顏色Light yellow to orange
二茂鐵氯喹價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2026/06/05HY-19364二茂鐵氯喹
Ferroquine
185055-67-85mg840元
2026/06/05HY-19364二茂鐵氯喹
Ferroquine
185055-67-810mg1475元
2026/06/05HY-19364二茂鐵氯喹
Ferroquine
185055-67-825mg2638元

常見問題列表

生物活性
Ferroquine (Ferrochloroquine),是 Chloroquine 的二茂鐵基類似物,是一種抗瘧疾劑。Ferroquine 通過誘導(dǎo)氧化應(yīng)激和隨后的膜破壞而對瘧原蟲表現(xiàn)出殺蟲作用。
靶點(diǎn)

antimalarial

體外研究

Ferroquine shows cytotoxicity against non-cancerous MRC-5 and HeLa cancer cells with IC 50 values of 24.4 μM and 16.8 μM, respectively.
24?hours post-incubation all newly transformed schistosomula (NTS) exposed to 33.3?μM Ferroquine shows strongly reduced viabilities.

體內(nèi)研究

Treatment of mice with 200 and 800?mg/kg Ferroquine, shows low total worm burden reductions of 19.4% and 35.6%. One of the mice treated with 800?mg/kg Ferroquine died within 24?hours post-treatment. No activity is observed treating mice with RQ at 200?mg/kg. Finally, a total worm burden reduction of 17.3% is observed following treatment with FQ-OH. Hence, modification of Chloroquine (CQ) by a ferrocenyl or ruthenocenyl fragment does not increase the antischistosomal properties of CQ. For comparison, at 200?mg/kg mefloquine (MQ) achieves a much higher worm burden reduction of 72.3% in S. mansoni -infected mice. A higher effect against female adult S. mansoni is also observed in MQ treated mice pointing to a sex-specific interference of these drugs with the target. Furthermore, in one of the FQ-OH treated mice many dead worms are recovered and a hepatic shift (i.e. worms migrating to the liver) observed. Hence, Ferroquine and FQ-OH show weak antischistosomal activity in vivo.

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