1883545-52-5

中文名稱 1883545-52-5

英文名稱 MM-102 (trifluoroacetate)

CAS 1883545-52-5

分子式 C37H50F5N7O6

分子量 783.84

MOL 文件 1883545-52-5.mol

更新日期 2024/11/15 18:20:31

1883545-52-5 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 1883545-52-5價(jià)格(試劑級(jí)) 常見問題列表

基本信息

中文別名

化合物MM-102 TFA

英文別名

MM-102 (TFA)
MM-102 (trifluoroacetate)
HMTASE INHIBITOR IX (TFA)
1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存

溶解度DMSO: ≥ 100 mg/mL (127.58 mM)

形態(tài)Solid

顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H302-H315-H319-H335

防范說明P261-P305+P351+P338

圖譜信息

1883545-52-5(1883545-52-5)核磁圖(¹HNMR)

1883545-52-5價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-12220A	1883545-52-5 MM-102 TFA	1883545-52-5	1 mg	486元
2026/06/05	HY-12220A	1883545-52-5 MM-102 TFA	1883545-52-5	5 mg	1463元
2026/06/05	HY-12220A	1883545-52-5 MM-102 TFA	1883545-52-5	10mg	2413元

常見問題列表

生物活性

MM-102 TFA (HMTase Inhibitor IX TFA) 是一種有效的 WDR5/MLL 相互作用抑制劑, WDR5 結(jié)合檢測(cè)中, IC50 =2.4 nM, Ki< 1 nM。

靶點(diǎn)

IC50: 2.4 nM (MLL).

體外研究

MM-102 (HMTase Inhibitor IX) inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins. MM-102 (TFA), with the highest binding affinities to WDR5, also show the most potent inhibitory activity in the HMT assay withIC ₅₀ =0.4-0.9 μM. MM-102 (HMTase Inhibitor IX) dose-dependently inhibits cell growth in the MV4;11 and KOPN8 leukemia cell lines, which carry MLL1-AF4 and MLL1-ENL fusion proteins, respectively. MM-102 (HMTase Inhibitor IX) has IC ₅₀ =25 μM in both cell lines and completely inhibits cell growth in these cell lines at 75 μM. MM-102 (HMTase Inhibitor IX) effectively and selectively inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins and has minimal effect in leukemia cells with wild-type MLL1 protein.