191868-14-1
中文名稱(chēng)
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
英文名稱(chēng)
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
CAS
191868-14-1
分子式
C31H36F3N7O5
分子量
643.67
MOL 文件
191868-14-1.mol
更新日期
2025/01/21 16:31:08
191868-14-1 結(jié)構(gòu)式
基本信息
中文別名
化合物BIBO3304 TFA 英文別名
BIBO 3304BIBO3304 TFA
BIBO 3304 (BIBO3304)
BIBO 3304 trifluoroacetate
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
物理化學(xué)性質(zhì)
儲(chǔ)存條件Store at +4°C
溶解度<75.77mg/ml in DMSO; <75.77mg/ml in ethanol
形態(tài)固體
顏色白色
InChIKeyFBMCYYWIBYEOST-NETKZVBLNA-N
SMILESC(F)(F)(F)C(=O)O.C(C1C=CC=CC=1)(C1C=CC=CC=1)C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC1C=CC(CNC(=O)N)=CC=1 |&1:23,r|
常見(jiàn)問(wèn)題列表
生物活性
BIBO3304 TFA 是一種高效的、具有口服活性的、選擇性的神經(jīng)肽Y (NPY) Y1 受體拮抗劑，對(duì)人和大鼠 Y1 受體均具有高親和力 (IC50 分別為 0.38 和 0.72 nM)。體內(nèi)研究
BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting.
BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY.
BIBO3304 TFA (0.5?μM; p.o.) significantly increases serum insulin levels.
| Animal Model: | Adult male Chbb:Thom rats weighing between 300 and 340 g |
| Dosage: | 30 μg |
| Administration: | bilateral paraventricular nucleus injection |
| Result: | Attenuated the hyperphagia following fasting, especially during the first 2 h of refeeding. |
| Animal Model: | 7-week-old C57BL/6JAusb mice |
| Dosage: | 0.5?μM |
| Administration: | p.o. |
| Result: | Significantly increased serum insulin levels. |