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191282-48-1

中文名稱 反-4-羧基-5-辛基-3-甲基-丁內(nèi)酯
英文名稱 C75
CAS 191282-48-1
分子式 C14H22O4
分子量 254.32
MOL 文件 191282-48-1.mol
更新日期 2024/12/13 09:53:00
191282-48-1 結(jié)構(gòu)式 191282-48-1 結(jié)構(gòu)式

基本信息

中文別名
C75反式
反-4-羧基-5-辛基-3-甲基-丁內(nèi)酯
脂肪酸合成酶FASN有效抑制劑(C75 TRANS)
反式-四氫-4-亞甲基-2-辛基-5-氧代-3-呋喃羧酸
英文別名
C75
C75 (trans)
C75 (racemic)
C 75 trC-75 trans-racemic
4-METHYLENE-2-OCTYL-5-OXOTETRAHYDROFURAN-3-CARBOXYLIC ACID
TETRAHYDRO-4-METHYLENE-2-OCTYL-5-OXO-3-FURANCARBOXYLIC ACID
(2R,3S)-4-METHYLIDENE-5-OXO-2-N-OCTYL-OXOLANE-3-CARBOXYLIC ACID
trans-4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
trans-Tetrahydro-4-Methylene-2-octyl-5-oxo-3-furancarboxylic Acid
(2S,3R)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid

物理化學性質(zhì)

沸點432.1±45.0 °C(Predicted)
密度1.08±0.1 g/cm3(Predicted)
儲存條件2-8°C
儲存條件2-8°C
溶解度DMSO: 18 mg/mL
溶解度二甲基亞砜:18 毫克/毫升
酸度系數(shù)(pKa)3.08±0.40(Predicted)
形態(tài)solid
顏色off-white

安全數(shù)據(jù)

危險性符號(GHS)有害 (GHS07)
GHS07
警示詞警告
危險性描述H317-H319
WGK Germany3
WGK Germany3
反-4-羧基-5-辛基-3-甲基-丁內(nèi)酯價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2026/06/05HY-12364A反-4-羧基-5-辛基-3-甲基-丁內(nèi)酯
trans-C75
191282-48-11 mg395元
2026/06/05HY-12364A反-4-羧基-5-辛基-3-甲基-丁內(nèi)酯
trans-C75
191282-48-15 mg790元
2026/06/05HY-12364A反-4-羧基-5-辛基-3-甲基-丁內(nèi)酯
trans-C75
191282-48-110 mM * 1 mL in DMSO869元

常見問題列表

生物活性
C75 trans (trans-C75, (±)-C75) 是一種 fatty acid synthase (FAS/FASN) 的新型有效的合成抑制劑,在成株試驗和球體生長測定中的IC50值分別為35 μM和50 μM。C75 可用作研究代謝紊亂和癌癥中脂肪酸合成的工具。
靶點
TargetValue
FASN
(clonogenic assay)
35 μM
FASN
(spheroid growth assay)
50 μM
體外研究

trans-C75 ((±)-C75) inhibits PC3 cell growht with an IC 50 of 35 μM at 24 h. trans-C75 ((±)-C75)(10-50 μM) also reduces the growth of LNCaP spheroids in a concentration-dependent manner with an IC 50 of 50 μM. trans-C75 ((±)-C75) inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. trans-C75 ((±)-C75) inhibits CPT1 and its administration produces anorexia, suggesting that central inhibition of CPT1 is essential for the anorectic effect of C75. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity.

體內(nèi)研究

C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA.

"191282-48-1" 相關(guān)產(chǎn)品信息
403-21-4 220227-21-4 82560-12-1 67686-01-5
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