19309-14-9
19309-14-9 結(jié)構(gòu)式
基本信息
小豆蔻明
小豆寇明
小豆蔻明對(duì)照品
豆寇明(小豆蔻明
小豆蔻明, >98%
豆蔻素、小豆蔻查耳酮
小豆蔻明, 來(lái)源于草豆蔻
小豆蔻明CARDAMOMIN
CARDAMONIN 小豆蔻明
Cardamonin
CARDAMONIN(RG)
(E)-Cardamonin
Cardamonin, >=98%
Alpinetin chalcone
Wnt/β-catenin Inhibitor, Cardamonin
(E)-2',4'-Dihydroxy-6'-methoxychalcone
Chalcone, 2', 4'-dihydroxy-6'-methoxy-
Cardamonin, 98%, from Alpinia katsumadai Hayata
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
| Target | Value |
|
NF-κB
(Cell-free assay) | |
|
TRPA1
(Cell-free assay) | 454 nM |
(E)-Cardamonin ((E)-Cardamomin) selectively blocksTRPA1 activation (IC 50 =454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. (E)-Cardamonin ((E)-Cardamomin) does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. (E)-Cardamonin ((E)-Cardamomin) suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.
(E)-Cardamonin ((E)-Cardamomin) (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia.