2188-68-3
中文名稱
鹽酸石蒜堿
英文名稱
Lycorine hydrochloride
CAS
2188-68-3
分子式
C16H17NO4
分子量
287.31
MOL 文件
2188-68-3.mol
更新日期
2026/07/14 13:32:51
2188-68-3 結(jié)構(gòu)式
基本信息
中文別名
水仙堿石蒜堿
石蕊堿
鹽酸石蒜堿
鹽酸石蒜堿(標(biāo)準(zhǔn)品)
石蒜堿鹽酸鹽對照品,
鹽酸石蒜堿(石蒜堿鹽酸鹽
異鼠李素-3-Β-D-蕓香糖甙
鹽酸石蒜堿, 96%(HPLC)
鹽酸石蒜堿(石蒜堿鹽酸鹽,水仙堿)
英文別名
LYCORINLYCORINE
(-)-LYCORINE
NARCISSIN(P)
Lycorine chloride
Hydrochloric Lycorine
Licorin hydrochloride
Lycorine hydrochloride
Licorine hydrochloride
Amarylline hydrochloride
所屬類別
原料藥：抗阿米巴病及抗滴蟲病藥物理化學(xué)性質(zhì)
外觀性狀白色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來源于石蒜鱗莖。
熔點(diǎn)206 °C
儲存條件Keep in dark place,Inert atmosphere,2-8°C
溶解度溶于水(15mg/毫升)
形態(tài)粉末
顏色白色至灰白色
穩(wěn)定性在-20°C下的水溶液可保存長達(dá)1個(gè)月。
InChI1S/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1
InChIKeyVUVNTYCHKZBOMV-NVJKKXITSA-N
SMILESCl.O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4[C@H]([C@@H]1O)[C@@H]23
鹽酸石蒜堿價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2026/07/06 | S3800 | 鹽酸石蒜堿 Lycorine hydrochloride | 2188-68-3 | 25mg | 876.57元 |
| 2026/06/05 | HY-N0289R | 鹽酸石蒜堿 Lycorine hydrochloride (Standard) | 2188-68-3 | 5 mg | 500元 |
| 2026/06/05 | HY-N0289R | 鹽酸石蒜堿 Lycorine hydrochloride (Standard) | 2188-68-3 | 10 mg | 750元 |
常見問題列表
生物活性
Lycorine hydrochloride 是石蒜的主要活性成分，也是黑色素瘤血管生成抑制劑，具有抗腫瘤活性。Lycorine hydrochloride 能有效抑制 Hey1B 細(xì)胞的有絲分裂增殖 (IC50 為 1.2 μM)。靶點(diǎn)
IC50: 1.2 μM (Hey1B cells )
體外研究
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected.
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
RT-PCR
| Cell Line: | C8161 cells |
| Concentration: | 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM |
| Incubation Time: | 48 hours |
| Result: | Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells. |
Western Blot Analysis
| Cell Line: | C8161 cells |
| Concentration: | 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM |
| Incubation Time: | 48 hours |
| Result: | Markedly reduced VE-cadherin protein levels in C8161 cells in a dose-dependent fashion. |
體內(nèi)研究
Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
| Animal Model: | 6- to 8-week-old BALB/C nude mice |
| Dosage: | 0 μg, 7.5 μg, 15 μg |
| Administration: | Subcutaneous injection; for 14 days |
| Result: | Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry. |