220810-26-4
中文名稱
醋酸組氨瑞林
英文名稱
Vantas
CAS
220810-26-4
分子式
C66H86N18O12
分子量
1323.52
MOL 文件
220810-26-4.mol
更新日期
2026/05/26 08:24:13
220810-26-4 結(jié)構(gòu)式
基本信息
中文別名
組氨瑞林乙酸鹽醋酸組氨瑞林雜質(zhì)
英文別名
VantasSupprelin la
Vantas USP/EP/BP
Histrelin acetate, >=98%
Histrelin Acetate(acetate)
Histrelin?Acetate impurity
(Des-Gly10,D-His(Bzl)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
所屬類別
生物化工：多肽物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml; PBS (pH 7.2): 10 mg/ml
形態(tài)結(jié)晶固體
顏色White to off-white
序列{Pyr}-His-Trp-Ser-Tyr-{d-His(Bzl)}-Leu-Arg-Pro-{NHEt}
應(yīng)用領(lǐng)域
用途一
Histrelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; Ki = 0.2 nM in CHO cells expressing the human receptor). It stimulates release of oxytocin and vasopressin ex vivo from the isolated rat hypothalamo-neurohypophysial system at a concentration of 100 nM. In vivo, the initial dose of histrelin (100 μg) stimulates acute increases in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone serum levels (50-, 2.5-, and 15-fold, respectively), while chronic treatment leads to 95% decreases in LH and FSH responses in rhesus monkeys. Formulations containing histrelin have been used in the treatment of advanced prostate cancer and central precocious puberty.