220810-26-4
中文名稱
醋酸組氨瑞林
英文名稱
Vantas
CAS
220810-26-4
分子式
C66H86N18O12
分子量
1323.52
MOL 文件
220810-26-4.mol
更新日期
2026/06/10 08:20:40
220810-26-4 結(jié)構(gòu)式
基本信息
中文別名
組氨瑞林乙酸鹽醋酸組氨瑞林雜質(zhì)
英文別名
VantasSupprelin la
Vantas USP/EP/BP
Histrelin acetate, >=98%
Histrelin Acetate(acetate)
Histrelin?Acetate impurity
(Des-Gly10,D-His(Bzl)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
所屬類別
生物化工：多肽物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml; PBS (pH 7.2): 10 mg/ml
形態(tài)結(jié)晶固體
顏色White to off-white
序列{Pyr}-His-Trp-Ser-Tyr-{d-His(Bzl)}-Leu-Arg-Pro-{NHEt}
應(yīng)用領(lǐng)域
用途一
Histrelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; Ki = 0.2 nM in CHO cells expressing the human receptor). It stimulates release of oxytocin and vasopressin ex vivo from the isolated rat hypothalamo-neurohypophysial system at a concentration of 100 nM. In vivo, the initial dose of histrelin (100 μg) stimulates acute increases in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone serum levels (50-, 2.5-, and 15-fold, respectively), while chronic treatment leads to 95% decreases in LH and FSH responses in rhesus monkeys. Formulations containing histrelin have been used in the treatment of advanced prostate cancer and central precocious puberty.常見問題列表
概述
醋酸組氨瑞林 一種 GnRH 類似物，是一種 GnRH 受體激動劑。Histrelin acetate 可增加血清中促黃體激素(LH)、促卵泡激素 (FSH) 和睪酮水平。Histrelin acetate 可用于前列腺癌、子宮內(nèi)膜異位癥的研究。