23256-42-0
23256-42-0 結(jié)構(gòu)式
基本信息
乳酸甲氧芐啶
乳酸甲氧芐氨嘧啶
甲氧芐氨嘧啶乳酸鹽
2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt
TRIMETHOPRIM LACTATE
TRIMETHOPRIM LACTATE SALT
TRIMETHOPRIM LACTIC ACID
lactic acid, compound with 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine (1:1)
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
toxic compounds or compounds which causing chronic effects
Repr. 2
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-B0510CR | 乳酸甲氧芐啶 Trimethoprim lactate (Standard) | 23256-42-0 | 10 mg | 340元 |
| 2026/06/05 | HY-B0510CR | 乳酸甲氧芐啶 Trimethoprim lactate (Standard) | 23256-42-0 | 25 mg | 660元 |
| 2026/06/05 | HY-B0510CR | 乳酸甲氧芐啶 Trimethoprim lactate (Standard) | 23256-42-0 | 50 mg | 1000元 |
常見問題列表
Dihydrofolate reductase
Bacteria
Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF).
Trimethoprim causes protein aggregation and induction of main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim presence leads to protein misfolding. Trimethoprim causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B are most efficiently induced by Trimethoprim and coaggregates with the insoluble proteins. Upon folate stress, deletion of the delta ibpA/B operon resulted in increased protein aggregation but does not influence cell viability.
In intraperitoneal infections in mice, the CD 50 values for Trimethoprim alone against H. influenzae , S. pneumoniae , E. coli and N. meningitidis , is 150 mg/kg, 335 mg/kg, 27.5 mg/kg and 8.4 mg/kg, respectively.