249537-73-3
中文名稱
NFAT INHIBITOR
英文名稱
H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
CAS
249537-73-3
分子式
C75H118N20O22S
分子量
1683.93
MOL 文件
249537-73-3.mol
更新日期
2026/07/20 08:31:36
249537-73-3 結(jié)構(gòu)式
基本信息
中文別名
化合物AGI-519811R-VIVIT游離態(tài)
NFAT INHIBITOR-1
細(xì)胞滲透性肽抑制劑多肽H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
L-蛋氨酰-L-丙氨酰甘氨酰-L-脯氨酰-L-組氨酰-L-脯氨酰-L-纈氨酰-L-異亮氨酰-L-纈氨酰-L-異亮氨酰-L-蘇氨酰甘氨酰-L-脯氨酰-L-組氨酰-L-ALPHA-谷氨酰-L-谷氨酸
英文別名
VIVITNFAT INHIBITOR
MAGPHPVIVITGPHEE
NFAT INHIBITOR?, >98%
NFAT Inhibitor (VIVIT peptide)
NFAT Inhibitor >96% (HPLC), solid
NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98%
MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU
H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
L-Glutamic acid, L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)1982.4±65.0 °C(Predicted)
密度1.334±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度DMSO: 15 mg/ml; Water: 10 mg/ml
酸度系數(shù)(pKa)3.12±0.10(Predicted)
形態(tài)solid
顏色White to off-white
水溶解性Soluble to 2 mg/ml in water
序列H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH
InChIKeyQPMHUXBSHGAVGD-MCDIZDEASA-N
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
安全說明22-24/25
WGK Germany3
WGK Germany3
海關(guān)編碼2933299090
存儲類別11 - Combustible Solids
應(yīng)用領(lǐng)域
參考質(zhì)量標(biāo)準(zhǔn)
外觀:白色粉末純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%
NFAT INHIBITOR價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-P1026 | NFAT INHIBITOR NFAT Inhibitor | 249537-73-3 | 1mg | 700元 |
| 2026/06/05 | HY-P1026 | NFAT INHIBITOR NFAT Inhibitor | 249537-73-3 | 5mg | 2800元 |
| 2026/06/05 | HY-P1026 | NFAT INHIBITOR NFAT Inhibitor | 249537-73-3 | 10mg | 4200元 |
常見問題列表
生物活性
NFAT Inhibitor (VIVIT peptide) 是一種 NFAT 的細(xì)胞滲透性肽抑制劑，可選擇性抑制鈣調(diào)磷酸酶介導(dǎo)的 NFAT 脫磷酸作用。靶點(diǎn)
Nuclear factor of activated Tcells (NFAT)
體外研究
NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.
Western Blot Analysis
| Cell Line: | Human peripheral blood CD14 + monocytes |
| Concentration: | 10 μM |
| Incubation Time: | 24 hours or 21 days |
| Result: | Short-term treatment with 10 μM, significantly inhibited nuclear translocation of NFATc1. Long-term treatment, significantly inhibited the cytoplasmic levels of cathepsin K, TRAP, and MMP-9. |