327036-89-5

中文名稱 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE

英文名稱 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE

CAS 327036-89-5

分子式 C10H10N2O2S

分子量 222.26

MOL 文件 327036-89-5.mol

更新日期 2026/05/25 13:08:17

327036-89-5 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 應(yīng)用領(lǐng)域圖譜信息 4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮價(jià)格(試劑級(jí)) 常見問(wèn)題列表

基本信息

中文別名

4-芐基-2-甲基-1,2,4-噻二唑烷-3,5-二酮
TDZD-8
TDZD 8
TDZD8
NP 01139
4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮
4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮 100MG

英文別名

NP 01139
TDZD-8/TDZD8
TDZD-8, >=98%
GSK-3InhibitorI,TDZD-8
1,2,4-Thiadiazolidine-3,5-dione,2-Methyl-4-(phenylMethyl)-
4-Benzyl-2-methyl-[1,2,4]thiadiazolidine-3,5-dione TDZD-8

所屬類別

生物化工：GSK-3 抑制劑

物理化學(xué)性質(zhì)

熔點(diǎn)63-64.4 °C

沸點(diǎn)335.5±35.0 °C(Predicted)

密度1.375±0.06 g/cm3(Predicted)

儲(chǔ)存條件2-8°C

溶解度DMSO: 18 mg/mL

溶解度二甲基亞砜：18 毫克/毫升

酸度系數(shù)(pKa)-2.08±0.20(Predicted)

形態(tài)needles

顏色white

InChIInChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

InChIKeyJDSJDASOXWCHPN-UHFFFAOYSA-N

SMILESS1C(=O)N(CC2=CC=CC=C2)C(=O)N1C

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 健康危害 (GHS08)

GHS08

警示詞危險(xiǎn)

危險(xiǎn)性描述H334

防范說(shuō)明P261-P342+P311

危險(xiǎn)品標(biāo)志Xi

危險(xiǎn)類別碼43

安全說(shuō)明36/37

WGK Germany3

海關(guān)編碼2934999090

存儲(chǔ)類別11 - Combustible Solids

應(yīng)用領(lǐng)域

用途1

Glycogen Synthase Kinase-3脽 is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazo lidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3脽 ( IC50 =2nM). Binds to the active site of GSK-3脽. Does not significantly affect the activities of Cd k-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).

圖譜信息

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE(327036-89-5)核磁圖(¹HNMR)

4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/07/06	S2926	4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE TDZD-8	327036-89-5	5mg	1181.41元
2026/07/06	S2926	4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE TDZD-8	327036-89-5	25mg	3013.59元
2026/06/06	B4436	4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	327036-89-5	5mg	100元

常見問(wèn)題列表

生物活性

TDZD-8 (NP 01139) 是一種非ATP競(jìng)爭(zhēng)性GSK-3β抑制劑，IC50為2 μM；對(duì)CDK1， casein kinase II， PKA和PKC具有最低限度的抑制效果。

靶點(diǎn)

Target	Value
GSK-3β	2 μM

體外研究

TDZD-8作為非ATP競(jìng)爭(zhēng)性抑制劑或與GS-1結(jié)合。在激酶實(shí)驗(yàn)中，TDZD-8對(duì)PKA, PKC, Cdk-1/cyclin B 和 CK-II 沒(méi)有抑制效果。 TDZD-8特異性誘導(dǎo)原代白血病細(xì)胞樣本發(fā)生細(xì)胞死亡。TDZD-8可以除去白血病祖細(xì)胞和干細(xì)胞。TDZD-8誘導(dǎo)細(xì)胞死亡，具有極其迅速的細(xì)胞死亡動(dòng)力學(xué)，且細(xì)胞膜完全喪失。TDZD-8作用于原代AML細(xì)胞樣本，抑制PKC和 FLT3。

體內(nèi)研究

TDZD-8 (TDZD8, 1?or 2?mg/kg, i.p.) both reduces the induction of p-DARPP32 following chronic L-dopa treatment in parkinsonian animals. TDZD8 treatment of 21 days induces a significant reduction in PKA expression in rats with established dyskinesia. Moreover, TDZD8 reduces FosB mRNA level in the striatum and lowers the expression of PPEB mRNA to similar levels as in 6-OHDA-lesioned rats without treated with L-dopa. The decrease in dyskinesia induced by TDZD8 is overcome by dopamine rceptor-1 agonist.

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