37413-91-5
37413-91-5 結(jié)構(gòu)式
基本信息
潑尼松雜質(zhì)12
醋酸四烯物(3TR)
布地奈德雜質(zhì)對照品6
16-四烯-3,20-二酮-21-醋酸酯
21-乙酰氧基孕甾-1,4,9(11),16-四烯-3,20-酮
21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯
21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯 100G
2-((8S,10S,13S,14S)-10,13-二甲基-3-氧代-6,7,8,10,12,13,14,15-八氫-3H-環(huán)戊二烯并[A]菲-17-基)-2-氧代乙基 乙酸酯
16-tetraen-21-yl
Tetraene acetate[3TR]
Prednisone Impurity 12
Acetate tetraene Matter
Tetraen-acetic acid complex
Pregna-1,4,9(11),16-tetraen
21-Hydroxy-1,4,9(11)-tetraene 21-acetate
21-Acetoxypregna-1,4,9(11),16-tetrene-3,20-dione
21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
物理化學(xué)性質(zhì)
制備方法
4380-55-6
37413-91-5
在氮?dú)獗Ｗo(hù)下，將50 g (0.13 mol) 孕-1,4,9(11)-三烯-3,20-二酮-17-羥基-21-乙酸酯與200 mL吡啶加入反應(yīng)瓶中，冷卻至-15℃，攪拌。隨后，加入30 g N-氯琥珀酰亞胺（NCS），并在1小時(shí)內(nèi)緩慢通入17.5 g (0.27 mol) SO2氣體，控制反應(yīng)溫度不超過-10℃。通氣完畢后，繼續(xù)攪拌半小時(shí)。反應(yīng)完成后，通過TLC監(jiān)測，確認(rèn)生成含有δ16甾族化合物（I）的混合溶液。將該混合溶液倒入300 mL濃鹽酸中，加入2000 mL冰水，靜置2小時(shí)以去除水溶性雜質(zhì)。分離水層后，濃縮有機(jī)層至少量液體，過濾得到固體，60℃干燥后獲得47 g δ16甾族化合物（I）。通過高效液相色譜（HPLC）測定，該δ16甾族化合物（I）的純度為99%。
參考文獻(xiàn)：
[1] Patent: CN105254697, 2016, A. Location in patent: Paragraph 0077; 0078; 0079; 0080; 0081
常見問題列表
Δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids. VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability.
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-136340 | 21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione | 37413-91-5 | 5 mg | 312元 |
| 2026/06/05 | HY-136340 | 21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione | 37413-91-5 | 10mM * 1mLin DMSO | 343元 |
| 2026/06/05 | HY-136340 | 21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione | 37413-91-5 | 10mg | 500元 |