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38937-66-5

中文名稱 軟木肟酸
英文名稱 Suberohydroxamic acid
CAS 38937-66-5
分子式 C8H16N2O4
分子量 204.22
MOL 文件 38937-66-5.mol
更新日期 2025/03/29 17:47:37
38937-66-5 結(jié)構(gòu)式 38937-66-5 結(jié)構(gòu)式

基本信息

中文別名
軟木肟酸
次異羥肟酸
辛烷-1,8-二氧肟酸
N1,N8-二羥基辛烷二酰胺
英文別名
ODHA
SBHA
[PTYR705]-STAT3
STAT3 (PTYR705)
SUBEROHYDROXAMIC ACID
SUBERIC BISHYDROXAMATE
SuberohydroxaMic acid 95%
SuberoylBis-hydroxamicAci
suberic bishydroxamic acid
SUBEROYL BISHYDROXAMIC ACID
所屬類別
化學(xué)試劑:羥胺

物理化學(xué)性質(zhì)

熔點153-155 °C(lit.)
密度1.219±0.06 g/cm3(Predicted)
儲存條件−20°C
溶解度H2O: soluble
酸度系數(shù)(pKa)9.18±0.20(Predicted)
形態(tài)lyophilized powder
顏色白色至淺米色
穩(wěn)定性吸濕性
InChI1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
InChIKeyIDQPVOFTURLJPT-UHFFFAOYSA-N
SMILESONC(=O)CCCCCCC(=O)NO

安全數(shù)據(jù)

安全說明22-24/25
WGK Germany3
海關(guān)編碼2928009090
存儲類別11 - Combustible Solids

常見問題列表

作用
Suberoylbis-hydroxamic酸(軟木肟酸)作為第二代異羥肟酸類組蛋白去乙酰化酶抑制劑,能夠抑制組蛋白去乙?;钢蠬DAC1和HDAC3的活性,小劑量、低濃度時可誘導(dǎo)腫瘤分化,并選擇性地抑制腫瘤生長而對正常細胞無明顯不良反應(yīng)。通過對乳腺癌的研究發(fā)現(xiàn)軟木肟酸呈時間、劑量依賴性抑制乳腺癌細胞增殖,使其停滯于G0~G1期。ChemicalBook
用途
軟木肟酸是一種組蛋白去乙?;敢种苿赡芫邆浼せ頝otch1信號通路的功能。應(yīng)用Western實驗檢驗Notch1信號通路被激活后所表達的活性蛋白NICD,來判斷軟木肟酸對Notch1信號通路的作用。
生物活性
Suberohydroxamic acid (suberic bishydroxamic acid)是競爭性HDAC抑制劑,對HDAC1和HDAC3的IC50分別為0.25 μM和0.3 μM。
靶點
TargetValue
HDAC1
(Cell-free assay)
0.25 μM
HDAC3
(Cell-free assay)
0.3 μM
體外研究

Suberoyl bis-hydroxamic acid (10, 20 or 50 μM; 24 hours) combination with TRAIL improves apoptosis extent, and when TRAIL is combined with 20 μM SBHA (itself causing only 10–15% apoptosis), resulting in 45–50% cell death.Suberoyl bis-hydroxamic acid (20-50 μM; 10-20 hours) alone has little effect on the expression of the proteins Bcl-xL, Mcl-1, and has albeit mildeffect on Bax. When it combines with TRAIL,which increases the ratio of relative protein expression of Bcl-xL and Bax in early periods, while the change in the ratio of Mcl-1 and Bax increases later in MM-BI and Ist-Mes2 cells.Suberoyl bis-hydroxamic acid (30 μM; 6 hours) causes accumulation of acetylated histone H4 in MEL cells.

Apoptosis Analysis

Cell Line: MM-BI and Ist-Mes2 cells
Concentration: 10 μM, 20 μM or 50 μM
Incubation Time: 24 hours
Result: Showed a cooperative effect in cell apoptosis.
體內(nèi)研究

Suberoyl bis-hydroxamic acid (intraperitoneal injection; 200 mg/kg; every 2 days; 12 days) reveals a marked increase in the active form of Notch1 (NICD) with a concomitant decrease in ASCL1. It reduces the MTC tumor growth.

Animal Model: Nude mice injected with human MTC cells
Dosage: 200 mg/kg
Administration: Intraperitoneal injection; every 2 days; 12 days
Result: Resulted in an average 55% inhibition of tumor growth in SBHA treatment group.
軟木肟酸價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2026/03/03S5905軟木肟酸
Suberohydroxamic acid
38937-66-525mg795.2元
2026/03/03S5905軟木肟酸
Suberohydroxamic acid
38937-66-51g7944.3元
2025/12/22HY-W009776軟木肟酸
Suberoyl bis-hydroxamic acid
38937-66-550mg100元
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