402473-54-5

中文名稱 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸

英文名稱 ONO-AE3-208

CAS 402473-54-5

分子式 C24H21FN2O3

分子量 404.43

MOL 文件 402473-54-5.mol

更新日期 2024/06/25 17:15:56

402473-54-5 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸價(jià)格(試劑級(jí)) 常見問題列表

基本信息

中文別名

4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸

英文別名

AE 3-208
ONO-AE3-208
AE 3-208
ONO AE3 208
ONO-AE3-208
AE 3-208
ONO AE3 208
4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido)phenyl)butanoic acid
4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]Benzenebutanoic acid
Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-

所屬類別

生物化工：激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)662.4±55.0 °C(Predicted)

密度1.30

儲(chǔ)存條件-20°C

溶解度≥40.4 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥8.1 mg/mL in EtOH with gentle warming and ultrasonic

酸度系數(shù)(pKa)4.69±0.10(Predicted)

形態(tài)粉末

顏色白色至米色

InChIInChI=1S/C24H21FN2O3/c1-15(18-11-12-21(25)20-7-3-2-6-19(18)20)24(30)27-22-13-16(14-26)9-10-17(22)5-4-8-23(28)29/h2-3,6-7,9-13,15H,4-5,8H2,1H3,(H,27,30)(H,28,29)

InChIKeyMTDIMKNAJUQTIO-UHFFFAOYSA-N

SMILESC1(CCCC(O)=O)=CC=C(C#N)C=C1NC(=O)C(C1=C2C(C=CC=C2)=C(F)C=C1)C

安全數(shù)據(jù)

WGK GermanyWGK 3

存儲(chǔ)類別11 - Combustible Solids

圖譜信息

4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸(402473-54-5)核磁圖(¹HNMR)

4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2025/12/22	HY-50901	4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸 ONO-AE3-208	402473-54-5	1 mg	444元
2025/12/22	HY-50901	4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸 ONO-AE3-208	402473-54-5	2mg	620元
2025/12/22	HY-50901	4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸 ONO-AE3-208	402473-54-5	10mM * 1mLin DMSO	916元

常見問題列表

生物活性

ONO-AE3-208 是一種 EP4 拮抗劑，能夠抑制前列腺癌細(xì)胞的侵襲，遷移與代謝。

靶點(diǎn)

EP4

體外研究

ONO-AE3-208 surpresses the in vitro cell invasion and migration in a dose-dependent manner without affecting cell proliferation. ONO-AE3-208 abolisheS CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid (AA) causeS dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208.

體內(nèi)研究

ONO-AE3-208 surpresses the in vivo bone metastasis of PC3 cells in mice. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls.