447410-57-3
中文名稱(chēng)
447410-57-3
英文名稱(chēng)
SB-756050
CAS
447410-57-3
分子式
C21H28N2O8S2
分子量
500.59
MOL 文件
447410-57-3.mol
更新日期
2026/07/13 11:29:13
447410-57-3 結(jié)構(gòu)式
基本信息
中文別名
化合物SB7560501,4-雙((3,4-二甲氧基苯基)磺酰基)-1,4-二氮雜環(huán)庚烷
英文別名
SB-756050SB-756050, >98%
SB756050
SB 756050
SB-756050
1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane
1H-1,4-Diazepine, 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro-
物理化學(xué)性質(zhì)
沸點(diǎn)653.1±65.0 °C(Predicted)
密度1.328±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.25 mg/ml; DMSO: 10 mg/ml
酸度系數(shù)(pKa)-6.97±0.20(Predicted)
形態(tài)結(jié)晶固體
顏色White to off-white
447410-57-3價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/07/06 | S6741 | 447410-57-3 SB-756050 | 447410-57-3 | 2mg | 1122.74元 |
| 2026/06/05 | HY-102016 | 447410-57-3 SB756050 | 447410-57-3 | 1 mg | 148元 |
| 2026/06/05 | HY-102016 | SB756050 | 447410-57-3 | 5 mg | 290元 |
常見(jiàn)問(wèn)題列表
生物活性
SB-756050是選擇性TGR5激動(dòng)劑，對(duì)人源TGR5的EC50值為1.3 μM。靶點(diǎn)
| Target | Value |
|
TGR5
() |
體外研究
TGR5 is a bile acid receptor and a potential target for the treatment of type 2 diabetes (T2D).
體內(nèi)研究
SB756050 is well‐tolerated; it is readily absorbed, exhibited nonlinear pharmacokinetics with a less than dose‐proportional increase in plasma exposure above 100 mg, and demonstrates no significant changes in exposure when co‐administered with sitagliptin. SB756050 demonstrates highly variable pharmacodynamic effects both within dose groups and between doses, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different.