53-06-5
中文名稱
可的松
英文名稱
CORTISONE
CAS
53-06-5
EINECS 編號(hào)
200-162-4
分子式
C21H28O5
MDL 編號(hào)
MFCD00003610
分子量
360.44
MOL 文件
53-06-5.mol
更新日期
2025/11/10 19:54:35
53-06-5 結(jié)構(gòu)式
基本信息
中文別名
17-羥-11脫氫皮質(zhì)(甾)酮可的松
腎上腺皮質(zhì)激素
11-去氫-17-羥基皮質(zhì)酮
17-羥-11-脫皮質(zhì)(甾)酮
11-去氫-17-羥皮質(zhì)甾酮
可體松
皮質(zhì)酮
17Α,21-二羥-4-孕烯-3,11,20-三酮
11-去氫-17-羥基皮質(zhì)酮,11-DEHYDRO-17-HYDROXYCORTICOSTERONE
17Α,21-二羥基-4-孕甾烯-2,11,20-三酮,17Α,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE
英文別名
11-DEHYDRO-17-HYDROXYCORTICOSTERONE17A 21-DIHYDROXY-4-PREGNEN-3 17 20-TRIONE
17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE
17ALPHA,21-DIHYDROXYPREGN-4-ENE-3,11,20-TRIONE
17ALPHA-HYDROXY-11-DEHYDROCORTICOSTERONE
17-HYDROXY-11-DEHYDROCORTICOSTERONE
4-PREGEN-17A,21-DIOL-3,11,20-TRIONE
4-PREGNEN-17,21-DIOL-3,11,20-TRIONE
4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONE
4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE
CORTISONE
CORTONE
DELTA4-PREGNENE-17, 21-DIOL-3, 11, 20-TRIONE
DELTA4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE
DELTA-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE
KENDALL'S CMPD ''E''
KENDALL'S COMPOUND E
KENDALL'S COMPOUND 'E'
KENDALL'S ''E''
REICHSTEIN'S COMPOUND ''FA''
所屬類別
生物化學(xué)品: 生化試劑: 激素物理化學(xué)性質(zhì)
外觀性狀白色結(jié)晶性粉末。Mp220-224℃(部分分解)，比旋光度[α]25D+209°(1.2%，95%乙醇)、[α]25546+269°(0.125%，苯)。溶于甲醇、乙醇、丙酮；微溶于乙醚、氯仿和苯；難溶于水，水溶液呈中性。在濃硫酸中呈橙紅色，并顯綠色熒光。
熔點(diǎn)223-228 °C (dec.)(lit.)
比旋光度D25 +209° (c = 1.2 in 95% alcohol); 25546 +269° (c = 0.125 in benzene); 25546 +248° (c = 0.1 to 0.2 in alcohol)
沸點(diǎn)412.46°C (rough estimate)
密度1.28±0.1 g/cm3 (20 ºC 760 Torr)
折射率210 ° (C=1, EtOH)
閃點(diǎn)9℃
儲(chǔ)存條件-20°C冷凍
溶解度Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Ethanol (Slightly, Heated)
酸度系數(shù)(pKa)12.37±0.60(Predicted)
形態(tài)固體
顏色白色至淺米色
水溶解性229.9mg/L(25 ºC)
Merck2539
主要應(yīng)用clinical testing
clinical testing
clinical testing
InChIKeyMFYSYFVPBJMHGN-ZPOLXVRWSA-N
SMILESO[C@]1([C@@]2([C@H]([C@H]3[C@@H]([C@]4(CCC(=O)C=C4CC3)C)C(=O)C2)CC1)C)C(=O)CO
LogP1.470
CAS 數(shù)據(jù)庫(kù)53-06-5(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H225-H301+H311+H331-H370
防范說(shuō)明P210-P260-P280-P301+P310-P311
危險(xiǎn)品標(biāo)志F,T,Xn
危險(xiǎn)類別碼11-23/24/25-39/23/24/25-63
安全說(shuō)明S22-S24/25
危險(xiǎn)品運(yùn)輸編號(hào)UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany3
RTECS號(hào)GM9020000
F18
海關(guān)編碼2937210000
存儲(chǔ)類別3 - Flammable liquids
危險(xiǎn)性類別Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1
應(yīng)用領(lǐng)域
用途一
生化研究；皮質(zhì)激素類藥物，具有抗炎、抗過(guò)敏等作用。參考質(zhì)量標(biāo)準(zhǔn)
mp215-225℃；比旋光度+207°；最大吸收波長(zhǎng)238nm。制備方法
方法一
以醋酸孕甾雙烯醇酮為原料，依次經(jīng)過(guò)氧化氫氧化、沃氏氧化、黑根菌生物氧化、鉻酐氧化得11-酮基-16，17α環(huán)氧黃體酮，經(jīng)氫溴酸開(kāi)環(huán)，氫化脫溴得粗品，再重結(jié)晶制得。常見(jiàn)問(wèn)題列表
應(yīng)用
可的松主要用于腎上腺皮質(zhì)功能減退癥的替代治療，但現(xiàn)在氫化可的松已優(yōu)先用于此癥。因?yàn)榭傻乃杀旧頍o(wú)活性，必需先在肝內(nèi)轉(zhuǎn)化成氫化可的松，某些肝臟疾病將影響其作用的可靠性。
生物活性
Cortisone是一種孕烷甾類激素，是身體應(yīng)對(duì)壓力應(yīng)激時(shí)釋放的主要物質(zhì)。它能抑制免疫系統(tǒng)，從而減少炎癥反應(yīng)和炎性疼痛、傷處腫脹。靶點(diǎn)
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Human Endogenous Metabolite
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體外研究
Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).
體內(nèi)研究
Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits.
| Animal Model: | Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion |
| Dosage: | 2 mg/kg |
| Administration: | Intramuscular injection on alternate days for 2 months |
| Result: |
Reduced the BCG lesions and tuberculin reactions.
Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive. |