55476-47-6
中文名稱
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
英文名稱
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
CAS
55476-47-6
分子式
C19H15NO3S
分子量
337.39
MOL 文件
55476-47-6.mol
55476-47-6 結(jié)構(gòu)式
基本信息
中文別名
化合物PSB-12062 英文別名
PSB-12062PSB-12062 >=98% (HPLC)
10-Tosyl-10H-phenoxazine
N-(p-Methylphenylsulfonyl)phenoxazine
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
10H-Phenoxazine, 10-[(4-methylphenyl)sulfonyl]-
物理化學(xué)性質(zhì)
儲(chǔ)存條件2-8°C
溶解度DMSO：可溶，2mg/mL，澄清（加熱）
形態(tài)粉末
顏色白色至米色
InChI1S/C19H15NO3S/c1-14-10-12-15(13-11-14)24(21,22)20-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)20/h2-13H,1H3
InChIKeyDHZNMEIBMACSFH-UHFFFAOYSA-N
SMILES[S](=O)(=O)(N2c3c(cccc3)Oc4c2cccc4)c1ccc(cc1)C
安全數(shù)據(jù)
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-101910 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine PSB-12062 | 55476-47-6 | 5mg | 340元 |
| 2026/06/05 | HY-101910 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine PSB-12062 | 55476-47-6 | 10mM * 1mLin DMSO | 374元 |
| 2026/06/05 | HY-101910 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine PSB-12062 | 55476-47-6 | 10mg | 550元 |
常見問題列表
生物活性
PSB-12062是有效，選擇性的 P2X4 拮抗劑，對(duì)人類 P2X4 的 IC50 值為1.38 μM。靶點(diǎn)
IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4)
體外研究
PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM).