58304-65-7
58304-65-7 結(jié)構(gòu)式
基本信息
1-氯-2-甲基丙基丙酸酯
丙酸-1-氯異丁酯1-CHLOROISOBUTYL PROPIONATE
PROPIONIC ACID-1-CHLOROISOBUTYL
1-CHLOROISOBUTYL PROPIONATE,85+%
1-Chloro-2-Methylpropyl Propanoate
1-Propanol, 1-chloro-2-methyl-, propanoate
1-Propanol, 1-chloro-2-methyl-, 1-propanoate
1-Chloroisobutyl propionate (Technical Grade)
物理化學(xué)性質(zhì)
制備方法
79-03-8
78-84-2
58304-65-7
在氮?dú)獗Ｗo(hù)下，將異丁醛（3g，41.6mmol）緩慢滴加至冷卻至0-5℃的丙酰氯（3.85g，41.6mmol）中，保持溫度在0-5℃范圍內(nèi)。反應(yīng)混合物在此溫度下持續(xù)攪拌4小時(shí)。反應(yīng)完成后，將混合物在50℃下進(jìn)行真空蒸餾，以除去揮發(fā)性組分，最終得到2.59g無(wú)色液體產(chǎn)物，即丙酸-1-氯異丁酯（產(chǎn)率：38%）。產(chǎn)物結(jié)構(gòu)通過(guò)1H-NMR和13C-NMR進(jìn)行確認(rèn)：1H-NMR (CDCl3, 500MHz) δ 1.06 (t, J = 7.0Hz, 6H), 7.60 (t, J = 7.5Hz, 3H), 2.13-2.17 (m, 1H), 2.39 (q, J = 7.5Hz, 2H), 6.31 (d, J = 4.5Hz, 1H); 13C-NMR (CDCl3, 125MHz) δ 8.66, 17.25, 17.36, 27.49, 35.19, 88.61, 172.16。
參考文獻(xiàn)：
[1] Patent: US2008/125483, 2008, A1. Location in patent: Page/Page column 9
[2] Patent: WO2009/118580, 2009, A2. Location in patent: Page/Page column 23-24
[3] Patent: US2014/56849, 2014, A1. Location in patent: Paragraph 0306-0308
[4] Patent: CN103626765, 2016, B. Location in patent: Paragraph 0402; 0404; 0405
[5] Journal of the American Chemical Society, 1921, vol. 43, p. 665