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65646-68-6

中文名稱 維甲酰酚胺
英文名稱 4-HYDROXYPHENYLRETINAMIDE
CAS 65646-68-6
分子式 C26H33NO2
MDL 編號(hào) MFCD00792674
分子量 391.55
MOL 文件 65646-68-6.mol
更新日期 2026/06/02 13:26:09
65646-68-6 結(jié)構(gòu)式 65646-68-6 結(jié)構(gòu)式

基本信息

中文別名
維甲酰酚胺
芬維A胺
英文別名
4HPR
4-HYDROXYPHENYLRETINAMIDE
FENRETINIDE
N-(4-HYDROXYPHENYL)-ALL-TRANS RETINAMIDE
N-(4-HYDROXYPHENYL)RETINAMIDE
RETINAMIDE
RETINOIC ACID P-HYDROXYANILIDE
hpr
n-(4-hydroxyphenyl)-retinamid
p-Hydroxyphenylretinamide
4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide
(2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenamide
Fenretinimide
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

熔點(diǎn)162-163°C
沸點(diǎn)597.6±42.0 °C(Predicted)
密度1.081±0.06 g/cm3(Predicted)
儲(chǔ)存條件−20°C
儲(chǔ)存條件-20°C
溶解度可溶于氯仿(少許)、甲醇(少許)
酸度系數(shù)(pKa)9.98±0.26(Predicted)
形態(tài)橙色固體
顏色黃色
生物來(lái)源synthetic (organic)
最大波長(zhǎng)(λmax)362nm(MeOH)(lit.)
Merck14,3998
穩(wěn)定性對(duì)光敏感,應(yīng)避光保存
InChIKeyAKJHMTWEGVYYSE-FXILSDISSA-N
SMILESC(NC1=CC=C(O)C=C1)(=O)/C=C(/C=C/C=C(/C=C/C1C(C)(C)CCCC=1C)\C)\C
CAS 數(shù)據(jù)庫(kù)65646-68-6(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)有害 (GHS07)健康危害 (GHS08)
GHS07,GHS08
警示詞危險(xiǎn)
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼60-61-20/21/22-36/37/38
危險(xiǎn)類別碼R60-R61-R20/21/22-R36/37/38
安全說(shuō)明53-26-36/37/39-45-52
安全說(shuō)明S53-S26-S36/37/39-S45
WGK Germany3
WGK Germany3
RTECS號(hào)VH6420000
海關(guān)編碼2924297099
存儲(chǔ)類別6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
危險(xiǎn)性類別Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Repr. 1B
Skin Irrit. 2
STOT SE 3

知名試劑公司產(chǎn)品信息

維甲酰酚胺價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-15373R維甲酰酚胺
Fenretinide (Standard)
65646-68-65 mg704元
2026/06/05HY-15373R維甲酰酚胺
Fenretinide (Standard)
65646-68-610 mg1056元
2026/06/05HY-15373R維甲酰酚胺
Fenretinide (Standard)
65646-68-625 mg1800元

常見(jiàn)問(wèn)題列表

生物活性
Fenretinide (4-HPR) 是一種合成的類維生素A衍生物,能夠結(jié)合視黃酸受體 (RAR) 誘導(dǎo)細(xì)胞死亡。
體外研究

Fenretinide (4-HPR) exerts not just acute but also long term antitumor activity in selected T-ALL cell lines. Fenretinide inhibits DES activity in CCRF-CEM leukemia cells in a dose and time dependent manner, leading to a concomitant increase of the endogenous cellular dhCer content. Fenretinide (3 μM)-induced dhCer accumulation in both CCRF-CEM and Jurkat cells. Ceramide inhibition with fenretinide protects insulin signaling. Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake. Fenretinide inhibits OVCAR-5 cell proliferation and viability at concentrations higher than 1 microM, with 70-90% growth inhibition at 10 microM. Fenretinide (1 microM) significantly inhibits OVCAR-5 invasion after 3 days preincubation. Endothelial cells treated with 1 microM 4-HPR fails to form tubes, but forms small cellular aggregates.

體內(nèi)研究

Fenretinide (4-HPR) (10 mg/kg, i.p.) selectively inhibits ceramide accumulation HFD-fed male C57Bl/6 mice. Fenretinide treatment improves glucose tolerance and insulin sensitivity as determined by both glucose and insulin tolerance tests. Addition of 25 mg/kg ketoconazole to Fenretinide in NOD/SCID mice increased 4-HPR plasma levels.

"65646-68-6" 相關(guān)產(chǎn)品信息
19094-56-5 65646-68-6 116-31-4
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