669008-26-8
中文名稱
1-甲基環(huán)丙烷磺酰胺
英文名稱
Cyclopropanesulfonamide, 1-methyl- (9CI)
CAS
669008-26-8
分子式
C4H9NO2S
分子量
135.18
MOL 文件
669008-26-8.mol
更新日期
2026/01/29 09:17:06
669008-26-8 結(jié)構(gòu)式
基本信息
中文別名
1-甲基環(huán)丙磺酰胺1-甲基環(huán)丙基磺酰胺
1-甲基-環(huán)丙烷磺胺
1-甲基環(huán)丙烷磺酰胺
1-甲基環(huán)丙烷-1-磺酰胺
1-甲基環(huán)丁烷-1-磺酰胺
英文別名
EOS-60413MethylcyclopropylsulfonaMide
1-MethylCyclopropanesulfonaMide
METHYL CYCLOPROPANE SULFONAMIDE
1-Methylcyclopropanesulphonamide
1-METHYL-CYCLOPROPYL SULFONAMIDE
1-Methylcyclopropane-1-sulfonamide
Cyclopropanesulfonamide, 1-methyl-
1-methyl-1-cyclopropanesulfonamide
Cyclopropanesulfomide, 1-methyl- (9CI)
所屬類別
醫(yī)藥中間體:原料藥中間體物理化學(xué)性質(zhì)
熔點103-104 °C(Solv: hexane (110-54-3))
沸點246.4±23.0 °C(Predicted)
密度1.34±0.1 g/cm3(Predicted)
儲存條件Sealed in dry,Room Temperature
酸度系數(shù)(pKa)10.93±0.20(Predicted)
外觀White to off-white Solid
InChIInChI=1S/C4H9NO2S/c1-4(2-3-4)8(5,6)7/h2-3H2,1H3,(H2,5,6,7)
InChIKeyATJVVVCODTXRAE-UHFFFAOYSA-N
SMILESC1(C)(S(N)(=O)=O)CC1
制備方法
方法1
849022-29-3
669008-26-8
第6步: 將Boc-1-甲基環(huán)丙烷磺酰胺2d6(151.8 mg,0.65 mmol)溶于二氯甲烷(6 mL)中,緩慢加入三氟乙酸(6 mL)。反應(yīng)混合物在室溫下攪拌3.5小時。反應(yīng)完成后,通過高真空蒸發(fā)去除溶劑,得到去保護(hù)的產(chǎn)物2d7,為灰白色蠟狀固體(79.1 mg,收率91%)。產(chǎn)物的結(jié)構(gòu)通過1H NMR(CDCl3,400 MHz)確認(rèn):δ 4.56(s,2H),1.58(s,3H),1.43-1.38(m,2H),0.85-0.80(m,2H)。
參考文獻(xiàn):
[1] Patent: US9527885, 2016, B2. Location in patent: Page/Page column 617
[2] Patent: US9643999, 2017, B2. Location in patent: Page/Page column 68; 69
[3] Patent: WO2006/7700, 2006, A1. Location in patent: Page/Page column 81
[4] Patent: US2006/19905, 2006, A1. Location in patent: Page/Page column 36
[5] Patent: WO2007/9227, 2007, A1. Location in patent: Page/Page column 43
