一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>67526-95-8

67526-95-8

中文名稱 毒胡蘿卜素
英文名稱 THAPSIGARGIN
CAS 67526-95-8
分子式 C34H50O12
MDL 編號 MFCD00083511
分子量 650.75
MOL 文件 67526-95-8.mol
更新日期 2026/05/19 11:22:59
67526-95-8 結構式 67526-95-8 結構式

基本信息

中文別名
毒胡蘿卜素, 來源于毒胡蘿卜
毒胡蘿卜素(>95% (HPLC),BC)
英文別名
THAPSIGARGIN
所屬類別
原料藥:抑制劑

物理化學性質

沸點597.77°C (rough estimate)
密度1.1521 (rough estimate)
RTECS號RH0325700
折射率1.6390 (estimate)
儲存條件−20°C
儲存條件-20°C
溶解度DMSO: soluble
溶解度可溶于DMSO
酸度系數(shù)(pKa)10.57±0.70(Predicted)
形態(tài)liquid or film
顏色無色
生物來源plant (Thapsia garganica)
敏感性感光
穩(wěn)定性DMSO或乙醇溶液可在-20°下穩(wěn)定儲存1周。
InChIKeyIXFPJGBNCFXKPI-FSIHEZPISA-N
SMILES[H][C@@]12C([C@H](OC([C@]3(O)C)=O)[C@]3(O)[C@@H](OC(CCC)=O)C[C@]2(C)OC(C)=O)=C(C)[C@H](OC(/C(C)=C(C)/[H])=O)[C@H]1OC(CCCCCCC)=O
CAS 數(shù)據(jù)庫67526-95-8(CAS DataBase Reference)

安全數(shù)據(jù)

危險性符號(GHS)有害 (GHS07)健康危害 (GHS08)
GHS07,GHS08
警示詞危險
危險性描述H315-H319-H334-H335
危險品標志Xn,T
危險類別碼36/37/38-42
危險類別碼R36/37/38-R42
安全說明26-36/37/39
安全說明S26-S36/37/39
危險品運輸編號UN 2811 6.1/PG 2
危險品運輸編號UN 2811 6.1/PG 2
WGK Germany3
WGK Germany3
海關編碼29181990
存儲類別11 - Combustible Solids
危險性類別Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
STOT SE 3

常見問題列表

用途
毒胡蘿卜素是廣泛使用的肌細胞內(nèi)質網(wǎng)Ca(2 +)-ATPases抑制劑。 它充當有效的,可滲透細胞的,不依賴IP3的細胞內(nèi)鈣釋放劑,可阻止血管生成抑制素和內(nèi)皮抑素誘導的細胞內(nèi)Ca2 +的瞬時增加。 它通過破壞細胞內(nèi)游離Ca2 +水平誘導細胞凋亡。
生物活性
Thapsigargin 是一種有效的、非競爭性的 the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) 的抑制劑,對carbachol誘導的[Ca2+]i瞬變在存不存在KCl預刺激條件下的IC50值分別為0.353 nM和0.448 nM。Thapsigargin 可誘導細胞凋亡。Thapsigargin 提取自植物Thapsia garganica。
靶點
TargetValue
SERCA
()
體外研究

Thapsigargin (0.001-?1 μM; for 2 and 4 days) arrests cell proliferations in MH7A human rheumatoid arthritis synovial cells in a time- and dose-dependent manner.
Thapsigargin (0.001-?1 μM; for 2 and 4 days) induces cell apoptosis in MH7A cells in a time- and dose-dependent manner.
Thapsigargin (0.001-?1 μM; for 2 and 4 days) impairs mTOR activity and leads to cyclin D1 expressions in MH7A cells.
Thapsigargin inhibits Ca 2+ entry into human neutrophil granulocytes.
Thapsigargin inhibits the carbachol-evoked [Ca 2+ ]i-transients with (IC 50 =0.353 nM) or without (IC 50 =0.448 nM) a KCl-prestimulation, but an additional small component, with a much lower sensitivity (IC 50 =4814 nM), is observed in the absence of a KCl-prestimulation. In contrast, the KCl-evoked [Ca 2+ ]i-transients displayed only one component with a very low sensitivity to Thapsigargin in both absence (IC 50 =3343 nM) and presence (IC 50 =6858 nM) of a carbachol-prestimulation.

Cell Proliferation Assay

Cell Line: MH7A human rheumatoid arthritis synovial cells
Concentration: 0.001, 0.1, and 1?μM
Incubation Time: For 2 and 4 days
Result: Arrested cell proliferations in a time- and dose-dependent manner.

Apoptosis Analysis

Cell Line: MH7A human rheumatoid arthritis synovial cells
Concentration: 0.001, 0.1, and 1?μM
Incubation Time: For 2 and 4 days
Result: Induces cell apoptosis in a time- and dose-dependent manner.

Western Blot Analysis

Cell Line: MH7A human rheumatoid arthritis synovial cells
Concentration: 0.001, 0.1, and 1?μM
Incubation Time: For 2 and 4 days
Result: Impairs mTOR activity and leads to cyclin D1 expressions
體內(nèi)研究

Thapsigargin (Injection; 0.25 ug/g, 0.5 ug/g and 1 ug/g; 24 hours) significant increases of 2 to 5-fold in chemokine and pro-inflammatory expression. Thapsigargin is more sensitive to inducing a systemic immune response.

Animal Model: Male Balb/c mice (20-25 g)
Dosage: 0.25 ug/g, 0.5 ug/g and 1 ug/g
Administration: Injection; 24 hours
Result: Increased of 2 to 5-fold in chemokine and pro-inflammatory expression.

知名試劑公司產(chǎn)品信息

毒胡蘿卜素價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2026/03/0332857毒胡蘿卜素 5MG
Thapsigargin, 97%, Thermo Scientific Chemicals
67526-95-85mg4473元
2026/03/03S7895毒胡蘿卜素
Thapsigargin
67526-95-81mg1392.3元
2026/03/03S7895毒胡蘿卜素
Thapsigargin
67526-95-85mg3990元
"67526-95-8" 相關產(chǎn)品信息
19329-89-6 96-05-9 106-72-9 4026-18-0 67526-95-8
酉阳| 蛟河市| 博白县| 崇州市| 保康县| 福州市| 北票市| 吉木乃县| 兰州市| 龙州县| 汉川市| 保亭| 舞阳县| 乌什县| 修水县| 磐安县| 华蓥市| 阳原县| 海宁市| 太康县| 加查县| 本溪| 金坛市| 博罗县| 通州市| 天全县| 星座| 武威市| 金昌市| 礼泉县| 杭锦后旗| 根河市| 龙胜| 景泰县| 松潘县| 鄢陵县| 江都市| 新巴尔虎左旗| 雷波县| 霍山县| 石泉县|