68047-06-3
68047-06-3 結(jié)構(gòu)式
基本信息
4-羥基他莫昔芬
(Z)-4-羥基三苯氧胺
4-羥基三苯氧胺 10MG
4-羥基三苯氧胺(Z異構(gòu)體)
4-羥基三苯氧胺(Z異構(gòu)體和E
4-羥基三苯氧胺(Z異構(gòu)體≥7
4-羥基三苯氧胺(Z異構(gòu)體≥70%)
4-羥基三苯氧胺(Z異構(gòu)體和E異構(gòu)體)
(Z)-4-(1-[4-(二甲氨基乙氧基)苯基]-2-苯基-1-丁烯基)苯酚
C05011
ici79,280
(Z)-4-OHT
hydroxytamoxifen
4-HYDROXYTAMOXIFEN
TAMOXIFEN, 4-HYDROXY-
cis-4-Hydroxytamoxifen
trans-4-Hydroxytamoxifen
See H9711, H9712, or H9716
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/12/22 | HY-16950 | 4-羥基三苯氧胺 4-Hydroxytamoxifen | 68047-06-3 | 1 mg | 320元 |
| 2025/12/22 | HY-16950 | 4-羥基三苯氧胺 4-Hydroxytamoxifen | 68047-06-3 | 10mM * 1mLin DMSO | 639元 |
| 2025/12/22 | HY-16950 | 4-羥基三苯氧胺 4-Hydroxytamoxifen | 68047-06-3 | 5 mg | 750元 |
常見問題列表
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Estrogen receptor 3.3 nM (IC 50 ) |
CRISPR/Cas9
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4-Hydroxytamoxifen (Monohydroxytamoxifen) is a selective oestrogen receptor antagonist, with an IC 50 of 3.3 nM for the [ 3 H]oestradiol binding to oestrogen receptor. 4-Hydroxytamoxifen (10, 100 nM) enables to inhibit the binding of [ 3 H]oestradiol to the human 8 S oestrogen receptor. 4-Hydroxytamoxifen activates intein-linked inactive Cas9, reduces off-target CRISPR-mediated gene editing. In human cells, conditionally active Cas9s modify target genomic sites with up to 25-fold higher specificity than wild-type Cas9.
4-Hydroxytamoxifen (0.2, 1 and 5 μg/day, p.o.) causes a dose-related decrease in uterine wet weight of immature rats. 4-Hydroxytamoxifen (6 μg/0.1 mL sesame oil/day, s.c.) effectively attenuates methamphetamine-induced nigrostriatal dopamine depletions in bothsexes of intact and gonadectomized C57BL/6 J mice. 4-Hydroxytamoxifen does not alter the dopamine content levels in the striatum.