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748810-28-8

中文名稱 鹽酸維那卡蘭
英文名稱 VERNAKALANT HYDROCHLORIDE
CAS 748810-28-8
分子式 C20H32ClNO4
分子量 385.93
MOL 文件 748810-28-8.mol
更新日期 2026/05/22 08:53:47
748810-28-8 結(jié)構(gòu)式 748810-28-8 結(jié)構(gòu)式

基本信息

中文別名
鹽酸弗納卡蘭
鹽酸維那卡蘭
英文別名
D06665
Vernakalant HCl
RSD1235 hydrochloride
RSD 1235 hydrochloride
RSD-1235 hydrochloride
VERNAKALANT HYDROCHLORIDE
Vernakalant hydrochloride (usan)
Vernakalant ((3R,1'R,2'R)-Isomer) HCl
RSD1235 HYDROCHLORIDE
RSD 1235 HYDROCHLORIDE
RSD-1235 HYDROCHLORIDE
(R)-1-((1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexyl)pyrrolidin-3-ol hydrochloride
所屬類別
生物:小分子化合物

物理化學(xué)性質(zhì)

熔點151-153oC
儲存條件Hygroscopic, Refrigerator, under inert atmosphere
溶解度DMSO (Slightly), Methanol (Slightly)
形態(tài)Solid
顏色White to Pale Yellow
InChI1S/C20H31NO4.ClH/c1-23-19-8-7-15(13-20(19)24-2)10-12-25-18-6-4-3-5-17(18)21-11-9-16(22)14-21;/h7-8,13,16-18,22H,3-6,9-12,14H2,1-2H3;1H/t16-,17-,18-;/m1./s1
InChIKeyJMHYCBFEEFHTMK-IIUXMCBISA-N
SMILESCl.N3(C[C@@H](CC3)O)[C@H]1[C@@H](CCCC1)OCCc2cc(c(cc2)OC)OC

安全數(shù)據(jù)

鹽酸維那卡蘭價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/12/22HY-14183鹽酸維那卡蘭
Vernakalant Hydrochloride
748810-28-81 mg600元
2025/12/22HY-14183鹽酸維那卡蘭
Vernakalant Hydrochloride
748810-28-82mg950元
2025/12/22HY-14183鹽酸維那卡蘭
Vernakalant Hydrochloride
748810-28-810mM * 1mLin DMSO1528元

常見問題列表

生物活性
Vernakalant hydrochloride 是一種混合電壓和頻率依賴性的 Na+ 和 K+ 通道阻斷劑。Vernakalant 抑制 Kv1.5 channelwt,Kv1.5 channelI508F,Kv1.5 channelT479A,IC50 分別為 13.35±0.93 μM。
靶點

IC50: 13.35±0.93 μM (Kv1.5 channel wt ), 0.61±0.03 μM ( I508F ), 1.63±0.09 μM (Kv1.5 channel T479A )

體外研究

Block of Kv1.5 by Vernakalant Hydrochloride is mediated after channel activation, because Vernakalant causes a relatively rapid onset of block of channel current upon depolarization but little evidence of resting or “tonic” block of the channel. In the presence of 10 μM Vernakalant, rapid block is apparent after channel opening, and a steady-state current level is rapidly reached. The most important effect is the reduction in potency for Vernakalant centered at I502A, which had an IC 50 of 329±19 μM (n=4-10), compared with a control IC 50 of 13.4±0.9 μM (n=5-23), which is a 25-fold decrease in potency. V505A, I508A, T480A, and C500A showed lesser reductions in potency on Kv1.5, of between 3- and 4-fold. I508Y in our experiments increased the IC 50 for Vernakalant on Kv1.5 to 24.7 μM, again similar to the reported value for hERG.

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