773-76-2
中文名稱
5,7-二氯-8-羥基喹啉
英文名稱
5,7-Dichloro-8-hydroxyquinoline
CAS
773-76-2
EINECS 編號
212-258-3
分子式
C9H5Cl2NO
MDL 編號
MFCD00006786
分子量
214.05
MOL 文件
773-76-2.mol
更新日期
2026/07/09 18:06:12
773-76-2 結(jié)構(gòu)式
基本信息
中文別名
5,7-二氯-8-羥基喹啉5,7-二氯-8-羧基喹啉
5,7-二氯-8-羥基氮雜萘
[克]氯辛
英文別名
5,7-DICHLORO-8-HYDROXYQUINOLINE5,7-DICHLORO-8-OXINE
5,7-DICHLORO-8-QUINOLINOL
AKOS BBS-00002684
CHLOROXINE
5,7-Dichlor-8-hydroxychinolin
5,7-Dichloro-8-hydroquinoline
5,7-Dichloro-8-hydroxyquinolin
5,7-Dichloro-8-oxychinolin
5,7-Dichloro-8-oxyquinoline
5,7-dichloro-8-quinolino
5,7-Dichlorooxine
5,7-Dichloroxine
8-Quinolinol,5,7-dichloro-
Capitrol
Chhoroox-ine
Chlofucid
CHQ
Clofuzid
component of Capitrol Cream Shampoo
所屬類別
醫(yī)藥中間體：喹啉類化合物物理化學性質(zhì)
外觀性狀無色或淡黃色針狀結(jié)晶。熔點180-181℃。溶于苯、丙酮、醚、二硫化碳、乙醇和濃硫酸，不溶于水，易溶于氫氧化鈉、氫氧化鉀呈黃色溶液。
熔點178-180 °C(lit.)
沸點305.47°C (rough estimate)
密度1.3320 (rough estimate)
折射率1.5500 (estimate)
儲存條件Sealed in dry,Room Temperature
溶解度Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated, Sonicated)
酸度系數(shù)(pKa)2.30±0.30(Predicted)
形態(tài)蓬松粉末
顏色淺米色
Merck14,2175
BRN153606
穩(wěn)定性Light Sensitive
InChI1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChIKeyWDFKMLRRRCGAKS-UHFFFAOYSA-N
SMILESOc1c(Cl)cc(Cl)c2cccnc12
CAS 數(shù)據(jù)庫773-76-2(CAS DataBase Reference)
NIST化學物質(zhì)信息8-Quinolinol, 5,7-dichloro-(773-76-2)
EPA化學物質(zhì)信息8-Quinolinol, 5,7-dichloro- (773-76-2)
安全數(shù)據(jù)
警示詞危險
危險性描述H302-H315-H318-H335
危險品標志Xn,Xi
WGK Germany3
RTECS號VC5350000
TSCAYes
海關(guān)編碼29334900
存儲類別11 - Combustible Solids
危險性類別Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
制備方法
方法一
由8-羥基喹啉經(jīng)氯化而得。將10g8-羥基喹啉溶于100g冰醋酸中，然后通過氯氣直至溶液成為金黃色為止。將反應物注入1升水中，即析出5g7-二氯-8-羥基喹啉，過濾后用200ml丙酮重結(jié)晶而得成品。5,7-二氯-8-羥基喹啉價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/07/06 | 11343 | 5,7-二氯-8-羥基喹啉,98% 5,7-Dichloro-8-hydroxyquinoline, 98%, Thermo Scientific Chemicals | 773-76-2 | 5g | 203元 |
| 2026/07/06 | S1839 | 5,7-二氯-8-羥基喹啉 Chloroxine | 773-76-2 | 50mg | 780.23元 |
| 2026/07/06 | S1839 | 5,7-二氯-8-羥基喹啉 Chloroxine | 773-76-2 | 1g | 5487.3元 |
常見問題列表
生物活性
Chloroxine是一種人工合成的抗菌化合物，加入洗發(fā)液中，有效治療頭皮屑和脂溢性皮炎。靶點
Bacterial
體外研究
By using the Jouyban-Acree model, the Chloroxine solubility is well correlated obtaining RAD values lower than 3.64% and RMSD values lower than 8.82?×?10 ?6 . Chloroxine is preferentially solvated by water for the studied mixtures in water-rich compositions; while within intermediate and co-solvent-rich compositions, Chloroxine is preferentially solvated by DMSO (DMF, NMP or 1,4-dioxane) in DMSO (DMF, NMP or 1,4-dioxane)?+?water mixtures. It is shown that the change in solvent-solvent interaction energy accounted by cavity term governed the solubility variation of Chloroxine in all aqueous mixtures.