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871361-88-5

中文名稱 SC 66
英文名稱 SC 66
CAS 871361-88-5
分子式 C18H16N2O
分子量 276.33
MOL 文件 871361-88-5.mol
更新日期 2026/05/25 13:08:16
871361-88-5 結(jié)構(gòu)式 871361-88-5 結(jié)構(gòu)式

基本信息

中文別名
化合物SC66
AKT抑制劑(SC66)
(2E,6E)-2,6-二(4-吡啶基亞甲基)環(huán)己酮
英文別名
SC 66
CS-2480
SC66
SC 66
(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone
Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-
所屬類別
生物化工:激動劑抑制劑

物理化學性質(zhì)

儲存條件Sealed in dry,2-8°C
溶解度DMSO:≥5mg/mL(加熱)
形態(tài)粉末
顏色淡黃色至深黃色
InChI1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+
InChIKeyCYVVJSKZRBZHAV-UNZYHPAISA-N
SMILESO=C1\C(CCC\C1=C/c2ccncc2)=C\c3ccncc3

安全數(shù)據(jù)

危險性符號(GHS)有害 (GHS07)
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
WGK Germany3
存儲類別13 - Non Combustible Solids

圖譜信息

SC 66價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/12/22HY-19832SC 66
SC66
871361-88-51 mg245元
2025/12/22HY-19832SC 66
SC66
871361-88-55mg550元
2025/12/22HY-19832SC 66
SC66
871361-88-510mM * 1mLin DMSO745元

常見問題列表

生物活性
SC66 是一種 Akt 抑制劑,降低細胞活力,這種作用存在劑量和時間依賴性,且抑制肝癌 (HCC) 細胞的集落形成和誘導凋亡。
靶點

Akt

體外研究

SC66 inhibits cell viability and colony forming capacity of HCC cells with IC 50 s of 0.77,0.47,0.92,0.75 and 2.85 μg/mL at 72 hours for HepG2, Hep3B, PLC/PRF/5,HA22T/VGH and Huh7 cells. HepG2, HA22T/VGH and PLC/PRF/5 cells have similar IC 50 s of approximately 0.85 and 0.75 μg/mL at 48 and 72 hours, respectively. To determine whether the decrease in cell viability is related to apoptosis induction, TUNEL assays are performed in Hep3B and Huh7 cells treated with 1, 2 and 4 μg/mL of SC66 for 24 hours. In Hep3B cells the number of TUNEL-positive cells increased with increasing concentrations of SC66, whereas in Huh7 cells very few light brown-colored cells are observed only after treatment with 4 μg/mL SC66.

體內(nèi)研究

To demonstrate the effectiveness in vivo of SC66 on HCC, a mouse xenograft tumor model of Hep3B cells is used. When tumors became palpable, at a size of about 150 mm 3 , mice are randomized into three groups of 6 animals each. The treated group receive SC66 at 15 and 25 mg/kg twice a week via i.p. injection, while the untreated group receive the vehicle alone. Treatment with 25 mg/Kg SC66 significantly reduces tumor volume to 37% on day 17 when compared with tumors of the untreated group.

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