87893-55-8
87893-55-8 結(jié)構(gòu)式
基本信息
15-DEOXY-Δ12,14-PROSTAGLANDIN J2
15d-PGJ?
15-Deoxy-Δ
15-deoxy-&Delta
delta12,14-Pgj 2
15-Deoxy-Δ12,14-PGJ2
12,14-prostaglandin J2
15-DEOXY-DELTA12,14-PGJ2
15-Deoxy-D-12,14-prostaglandin J2
15-Deoxy-delta12,14-prostaglandin
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
Flam. Liq. 2
STOT SE 3
常見問題列表
|
PPARγ 2 μM (EC 50 ) |
PPARδ
|
Human Endogenous Metabolite
|
15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic, α, β-unsaturated ketone (an enone) in the cyclopentenone ring. 15-Deoxy-Δ-12,14-prostaglandin J2 is one of the cyPGs whose functions in inflammation, cell proliferation, survival, and apoptosis have been documented. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ in a dose-dependent manner. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ’s transcriptional activity through formation of a covalent adduct between its endocyclic enone at C9 and Cys249 in the receptor’s ligand-binding domain.