950455-15-9
中文名稱
利普司他丁-1
英文名稱
Liproxstatin-1
CAS
950455-15-9
分子式
C19H21ClN4
分子量
340.85
MOL 文件
950455-15-9.mol
更新日期
2026/06/03 10:42:41
950455-15-9 結(jié)構(gòu)式
基本信息
中文別名
N-[(3-氯苯基)甲基]-螺[哌啶-4,2'(1'H)-喹喔啉]-3'-胺 英文別名
CS-1656Liproxstatin-1
Liproxstatin-1 USP/EP/BP
LIPROXSTATIN-1
LIPROXSTATIN1
N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine
N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4'-piperidine]-2-amine
N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxaline]-3'-amine
N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine
所屬類別
生物化工：Ferroptosis 抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)581.4±50.0 °C(Predicted)
密度1.32±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度溶于DMSO(15mg/ml)
酸度系數(shù)(pKa)9.45±0.40(Predicted)
形態(tài)粉末
顏色白色至淺棕色
穩(wěn)定性可在-20°C下的DMSO溶液保存長(zhǎng)達(dá)2個(gè)月。
InChIInChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
InChIKeyYAFQFNOUYXZVPZ-UHFFFAOYSA-N
SMILESN1CCC2(C(NCC3=CC=CC(Cl)=C3)=NC3=C(N2)C=CC=C3)CC1
常見問題列表
生物活性
Liproxstatin-1 是一種有效的 ferroptosis 抑制劑。體外研究
Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4?/?cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4?/?cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 μM), erastin (1 μM) and RSL3 (0.5 μM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 μM) and H2O2 (200 μM).體內(nèi)研究
Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.生物活性
Liproxstatin-1是一種有效的ferroptosis抑制劑，IC50為22 nM。靶點(diǎn)
| Target | Value |
|
ferroptosis
(Cell-free assay) | 22 nM |
體外研究
Liproxstatin-1能夠在低納摩爾范圍內(nèi)抑制鐵死亡和Gpx4
體內(nèi)研究
與溶劑對(duì)照組相比，Liproxstatin-1可顯著地延長(zhǎng)生存期，抑制管狀細(xì)胞中鐵死亡，減輕缺血/再灌注誘發(fā)的肝損傷中的組織損傷。