一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Hydrochlorothiazide
58-93-5

Hydrochlorothiazide synthesis

5synthesis methods
Hydrochlorothiazide, 1,1-dioxide 6-chloro-3,4-dihydro-2H-1,2,4- benzothiadiazin-7-sulfonamide (21.3.4), is synthesized either by cyclization of 4,6-sulfonamido- 3-chloroaniline (21.3.2) using paraformaldehyde, during which simultaneous reduction of the double bond occurs at position C3–C4, or the drug is synthesized by reduction of the same double bond in chlorothiazide (21.3.3) by formaldehyde. This small change in structure increases activity of the drug in comparison with chlorothiazide, and increases its absorbability when used orally.

-

Yield:58-93-5 93.9%

Reaction Conditions:

with potassium borohydride;acetic acid in methanol at -10 - 5; for 4 h;Reagent/catalyst;Solvent;

Steps:

2 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxidePreparation of matter

potassium borohydride (3.65 g, 67.6 mmol, 2 eq) was added to methanol (50 mL).The temperature was lowered to 0 to 5 ° C, and acetic acid (8.11 g, 135.2 mmol, 4 eq) was added dropwise at this temperature.After stirring for 1~2h,Cool down to -10 ° C,The compound chlorothiazide (10 g, 33.8 mmol, 1 eq) was added at this temperature.Maintain -10 ~ 5 ° C reaction for 4h,Filter by suction and rinse the filter cake with a small amount of methanol (10 mL).Get about 9.4g of white solid(Yield 93.9%).

References:

CN108658896,2018,A Location in patent:Paragraph 0063; 0067-0069; 0075; 0081; 0088; 0095; 0101

Hydrochlorothiazide Related Search:

松原市| 遂宁市| 三台县| 隆德县| 台南县| 阿拉善盟| 囊谦县| 伊川县| 大荔县| 哈巴河县| 芜湖县| 鹤壁市| 罗定市| 桂林市| 渝北区| 阳信县| 长岛县| 资兴市| 宁乡县| 安新县| 南丹县| 增城市| 宝丰县| 万山特区| 六枝特区| 盐边县| 卫辉市| 林周县| 临桂县| 墨玉县| 理塘县| 乌兰察布市| 长汀县| 彭水| 浦城县| 健康| 左权县| 芦山县| 保德县| 开封市| 崇文区|