2-HYDROXYACETOPHENONE synthesis
- Product Name:2-HYDROXYACETOPHENONE
- CAS Number:582-24-1
- Molecular formula:C8H8O2
- Molecular Weight:136.15
Yield:582-24-1 82%
Reaction Conditions:
with tetra-(n-butyl)ammonium iodide in acetonitrile;tert-butyl alcohol at 120; for 24 h;
Steps:
1 Example 1: Synthesis of -hydroxyacetophenone
To 25 mL pressure reaction tube was added acetonitrile 2mL,Benzaldehyde (31.8 mg, 0.3 mmol),Paraformaldehyde (27.0mg, 0.9 mmol),Tert-Butyl alcohol (83 mg, 2.0 eq.),Tetrabutylammonium iodide (22 mg, 0.2 eq.),The reaction was stirred magnetically in a 120 ° C oil bath for 24 hours.After the reaction was over, most of the solvent was distilled off under reduced pressure,The remaining mixture was separated by column chromatography using petroleum ether / ethyl acetate (10: 1)Get the desired product, a white solid,33.5 mg,Yield 82%
References:
Lishui College;Yan Guobing;Yu Jian;Wang Lianggui CN105061166, 2017, B Location in patent:Paragraph 0014; 0015; 0016
60-12-8
619 suppliers
$6.00/25g
582-24-1
261 suppliers
$8.00/5g
96-09-3
239 suppliers
$14.00/5g
582-24-1
261 suppliers
$8.00/5g
292638-84-7
0 suppliers
inquiry
582-24-1
261 suppliers
$8.00/5g