一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Evidence-based Complementary and Alternative Medicine >>article

Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms

Published:28 February 2020 DOI: 10.1155/2020/3109069 PMID: 32190080
Fangjun Chen,?Yifei Xu,?Jing Wang,?Xufeng Yang,?Hongying Cao,?Ping Huang

Abstract

In this study, we investigated the relaxation effect and mechanisms of patchouli alcohol (PA) on rat corpus cavernosum. Corpus cavernosum strips were used in organ baths for isometric tension studies. The results showed that PA demonstrated concentration-dependent relaxation effect on rat corpus cavernosum. The relaxant response to PA was not influenced by tetrodotoxin and atropine while it was significantly inhibited by removal of endothelium. L-NG-nitroarginine methyl ester (L-NAME, a nitric oxide synthase inhibitor) or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, a soluble guanylate cyclase inhibitor) significantly inhibited relaxation response to PA, whereas indomethacin (COX inhibitor) had no effect on PA-induced relaxation. The treatment of endothelium-deprived corpus cavernosum with several potassium channel blockers including tetraethylammonium (TEA), 4-aminopyridine (4-AP), and glibenclamide had no effect on PA-induced relaxation. Endothelium-deprived corpus cavernosal contractions induced by cumulative addition of Ca2+ to high KCl solution without CaCl2 were significantly inhibited by PA. Also, PA improved relaxant capacity of sildenafil in rat corpus cavernosum. In addition, the perfusion with PA significantly increased the levels of cGMP and expression of mRNA and protein of neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS). Furthermore, intracavernous injection of PA enhanced the rise in intracavernous pressure in rats during cavernosal nerve electric stimulation. In conclusion, PA relaxed the rat corpus cavernosum attributed to both endothelium-dependent and -independent properties. While the former component was mostly involved in nitric oxide signaling pathway, the endothelium-independent mechanism involved in PA-induced relaxation was probably linked to calcium antagonism.

Substances (19)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Indometacin 53-86-1 C19H16ClNO4 785 suppliers $15.00-$1700.00
Indometacin 53-86-1 C19H16ClNO4 785 suppliers $15.00-$1700.00
Indometacin 53-86-1 C19H16ClNO4 785 suppliers $15.00-$1700.00
Indometacin 53-86-1 C19H16ClNO4 785 suppliers $15.00-$1700.00
Glibenclamide 10238-21-8 C23H28ClN3O5S 747 suppliers $6.00-$625.00
Glibenclamide 10238-21-8 C23H28ClN3O5S 747 suppliers $6.00-$625.00
Glibenclamide 10238-21-8 C23H28ClN3O5S 747 suppliers $6.00-$625.00
Glibenclamide 10238-21-8 C23H28ClN3O5S 747 suppliers $6.00-$625.00
Phenylephrine 59-42-7 C9H13NO2 220 suppliers $23.30-$1654.38
Phenylephrine 59-42-7 C9H13NO2 220 suppliers $23.30-$1654.38

Similar articles

眉山市| 明星| 南溪县| 江达县| 南溪县| 马公市| 巴林左旗| 自治县| 友谊县| 昌图县| 宁晋县| 陆良县| 信丰县| 房产| 冕宁县| 连州市| 青州市| 嘉义市| 离岛区| 福建省| 达州市| 固原市| 浦城县| 永丰县| 巴南区| 会宁县| 铜梁县| 华亭县| 呼和浩特市| 开化县| 同仁县| 大厂| 河津市| 呈贡县| 宁化县| 罗山县| 宜兰县| 凤山市| 晋江市| 磴口县| 明溪县|