Rupatadine
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- CAS-Nr.
- 158876-82-5
- Englisch Name:
- Rupatadine
- Synonyma:
- Rupatidine;Rupax;Rupafi;Rupafin;Pafinur;Rinialer;UR-12592;RUPATADINE;ROPATADINE;Alergoliber
- CBNumber:
- CB1346639
- Summenformel:
- C26H26ClN3
- Molgewicht:
- 415.96
- MOL-Datei:
- 158876-82-5.mol
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Rupatadine Eigenschaften
- Schmelzpunkt:
- 58-61°C
- Siedepunkt:
- 586.4±50.0 °C(Predicted)
- Dichte
- 1.233±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- L?slichkeit
- Dichloromethane; Ethyl Acetate
- Aggregatzustand
- Oil
- pka
- 6.95±0.20(Predicted)
- InChI
- 1S/C26H26ClN3/c1-18-13-19(16-28-15-18)17-30-11-8-20(9-12-30)25-24-7-6-23(27)14-22(24)5-4-21-3-2-10-29-26(21)25/h2-3,6-7,10,13-16H,4-5,8-9,11-12,17H2,1H3
- InChIKey
- WUZYKBABMWJHDL-UHFFFAOYSA-N
- SMILES
- CC1=CN=CC(CN2CCC(CC2)=C3C4=CC=C(C=C4CCC5=CC=CN=C35)Cl)=C1
- CAS Datenbank
- 158876-82-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral
Aquatic Chronic 4 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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Rupatadine Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Rupatadine is off white to pinkish crystalline powder. It is soluble in methanol and ethanol slightly soluble in Chloroform and insoluble inwater.
Verwenden
Rupatadine Fumarate is a dual antagonist of histamine H1 and platelet-activating factor receptors. Rupatadine fumarate has been approved for the treatment of allergic rhinitis and chronic urticaria in adults and children over 12 years.
Mode of action
Rupatadine is a second generation, non-sedating, long-acting histamine antagonist with selective peripheral H1receptor antagonist activity. It further blocks the receptors of the platelet-activating factor (PAF) according to in vitro and in vivo studies.
Rupatadine possesses anti-allergic properties such as the inhibition of the degranulation of mast cells induced by immunological and non-immunological stimuli, and inhibition of the release of cytokines, particularly of the tumor necrosis factors (TNF) in human mast cells and monocytes.
Rupatadine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Rupatadine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 173)Lieferanten
158876-82-5()Verwandte Suche:
Methylsalicylat
Betahistindihydrochlorid
Bensulfuron methyl
Methyl-4-hydroxybenzoat
2,4,6-Trimethylpyridin
4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat
4-Methylpyridin
Stavudine
Olopatadine
2,5-Dimethylpyridin
2-Chloro-5-chloromethylpyridine
2,6-Dimethylpyridin
2-[[[[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester
Kresoxim-methyl
Dimethylfumarat
Eisen(II)fumarat
Thiophanat-methyl
2,2,6,6-Tetramethylpiperidin-4-ol
- 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidylidene]-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
- 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine (2E)-2-Butenedioate
- Rupafi
- RUPATADINEFUMARATE(FORR&DONLY)
- RUPATADINE FREE BASE
- 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-β]pyridine (2E)-2-Butenedioate
- Rupafin
- 5H-Benzo(5,6)cyclohepta(1,2-B)pyridine, 8-chloro-6,11-dihydro-11-(1-((5-methyl-3-pyridinyl)methyl)-4-piperidinylidene)-
- Unii-2ae8m83G3e
- Rupatidine FuMerate
- Alergoliber
- Pafinur
- Rinialer
- Rupax
- 8-Chloro-11-(1-((5-methylpyridin-3-yl)methyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclo
- Rupatadine fuMerate
- 8-Chloro-11-(1-((5-Methylpyridin-3-yl)Methyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
- UR-12592
- 8-Chloro-11-(1-((5-methylpyridin-3-yl)methyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cy
- RUPATADINE
- 8-chloro-11-[1-[(5-methylpyridin-3-yl)methyl]piperidin-4-ylidene]-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
- 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
- ROPATADINE
- Rupatadine (UR-12592)
- Lupatadine in methanol
- Rupatidine
- 158876-82-5
- C30H30ClN3O4
- C26H26ClN3C4H4O4
- API
- Heterocyclic Compounds
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Rupatadine
- Pharmaceutical material and intermeidates
- APIs
